4543-96-8

Basic information

• Product Name: N,N,N'-TRIMETHYL-1,3-PROPANEDIAMINE
• Synonyms: N N N'-TRIMETHYLTRIMETHYLENEDIAMINE;N,N,N'-TRIMETHYL-1,3-PROPANEDIAMINE;1,3-Propanediamine, N,N,N'-trimethyl-;3-Dimethylamino-N-methylpropylamine;n,n,n’-trimethyl-3-propanediamine;N,N,N'-trimethylpropane-1,3-diamine;stabilisedwithKOH;PROPANEDIAMINENNNTRIMETHYL
• CAS NO: 4543-96-8
• Molecular Formula: C₆H₁₆N₂
• Molecular Weight: 116.2
• EINECS: 224-901-5
• Product Categories: Nitrogen Compounds;Organic Building Blocks;Polyamines
• Mol File: 4543-96-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: -7.15°C (estimate)
• Boiling Point: 140-142 °C(lit.)
• Flash Point: 94 °F
• Appearance: Clear colorless/Liquid
• Density: 0.793 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.4283(lit.)
• Storage Temp.: Flammables area
• PKA: 10.61±0.10(Predicted)
• Water Solubility: Soluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: N,N,N'-TRIMETHYL-1,3-PROPANEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N,N'-TRIMETHYL-1,3-PROPANEDIAMINE(4543-96-8)
• EPA Substance Registry System: N,N,N'-TRIMETHYL-1,3-PROPANEDIAMINE(4543-96-8)

Safety Data

• Hazard Codes: C
• Statements: 10-20/21/22-34
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 2734 8/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 4543-96-8(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless liquid

Uses

N,N,N′-Trimethyl-1,3-propanediamine was used in preparation of unlabelled N,N,N′-trimethyl-[2-hydroxy-3-methyl-5-iodobenzyl]-1,3-propanediamine (HIDPM).

Upstream product

• 69721-81-9 N-(3-Dimethylamino-propyl)-4,N-dimethyl-benzenesulfonamide 
• 13474-65-2 N,N-dimethyl-N-(3-phthalimidopropyl)amine 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 
• 74-89-5 methylamine 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 5922-69-0 N-[3-(dimethylamino)propyl]formamide 

Downstream Products

• 101724-86-1 (+/-)-trans-2-[(3-Dimethylamino-propyl)-methyl-amino]-cyclohexanol 
• 67440-34-0 (1S,2S)-2-[(3-Dimethylamino-propyl)-methyl-amino]-cyclopentanol 
• 19077-20-4 2-chloro-10-(3-(N-(3-dimethylamino)propyl-N-methyl)amino)propyl-10H-phenothiazine 
• 263268-88-8 N-[2-methyl-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]-5-[N-(3-dimethylaminopropyl)-N-methylamino]-2-nitrobenzamide 
• 882670-53-3 N-(3-(dimethylamino)propyl)-N-methyl-2-nitro-4-(trifluoromethyl)benzenesulfonamide 
• 56756-20-8 N¹-(4-chloro-2-nitrophenyl)-N³,N³-dimethylpropane-1,3-diamine 
• 1207273-31-1 ANSPh 
• 1191929-46-0 2-amino-6-(5-{2-[N-(3-dimethylaminopropyl)-N-methylamino]-5-trifluoromethylbenzamide}-2-methylphenyl)-7-methoxy-8-(4-pyridyl)quinazoline 
• 1072193-31-7 (4S,4aS,5aR,12aS)-4-dimethylamino-7-(3-{[(3-dimethylamino-propyl)-methyl-amino]-methyl}-phenyl)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide 

Relevant articles and documents

Reversible zwitterionic liquids, the reaction of alkanol guanidines, alkanol amidines, and diamines with CO2

Alkanolamidines, alkanolguanidines and diamines each react with CO 2 to form reversible zwitterionic liquids. CO2 is chemically bound to the alcohol on alkanolamidines and alkanolguanidines as zwitterionic alkylcarbonates, while CO2 is chemically bound on diamines as zwitterionic carbamates. All three classes of zwitterionic liquids could be reverted to their non-ionic forms by thermally stripping the CO 2 at temperatures near 50 °C, while one derivative was found to irreversibly form a cyclic carbonate.

A complete series of 6-deoxy-monosubstituted tetraalkylammonium derivatives of α-, β-, and γ-cyclodextrin with 1, 2, and 3 permanent positive charges

An efficient synthetic route toward the preparation of a complete series of monosubstituted tetraalkylammonium cyclodextrin (CD) derivatives is presented. Monotosylation of native CDs (α-, β-, γ-) at position 6 gave the starting material. Reaction of monotosylate (mono-Ts-CD) with 45% aqueous trimethylamine gave CDs substituted with one cationic functional group in a single step. Derivatives equipped with a substituent containing two cationic sites separated by an ethylene or a propylene linker were prepared by reacting mono-Ts-CD with neat N,N,N'-trimethylethane-1,2-diamine or N,N,N'- trimethylpropane-1,3-diamine and subsequent methylation by CH3I in good yields. Finally, analogues bearing a moiety with three tetraalkylammonium sites were synthesized by reacting mono-Ts-CD with bis(3-aminopropyl)amine and subsequent methylation. The majority of the presented reactions are very straightforward with a simple work-up, which avoids the need of chromatographic separation. Thus, these reactions are suitable for the multigram-scale production of monosubstituted cationic CDs. 2014 Popr et al;.

METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS

The invention features a method for treating chronic pain using a compound selected from formulae (I), (II)A, (I)B and (I)C.