1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester
• CAS No.: 190846-24-3
• Molecular Formula: C16H23NO5S
• Molecular Weight: 341.42300

Synonyms:N-Benzyloxycarbonyl-2(S)-(2-methanesulphonyloxyethyl)piperidine;N-benzyloxycarbonyl-2(RS)-(2-methanesulfonyloxyethyl)piperidine;2-(2-Methanesulfonyloxy-ethyl)-piperidine-1-carboxylic acid benzyl ester;

Chemical Property of 1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester

Chemical Property:

• Boiling Point: 509.9±33.0 °C(Predicted)
• PSA: 81.29000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 3.56270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester

There total 4 articles about 1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanesulfonyl chloride (124-63-0) + 2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester (39945-50-1) → 2-(2-Methanesulfonyloxy-ethyl)-piperidine-1-carboxylic Acid Benzyl Ester (190846-24-3)

Guidance literature:

With triethylamine; In dichloromethane; at 17 ℃; for 0.416667h;

DOI:10.1021/jm011133d

Reference yield:

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) → 2-(2-Methanesulfonyloxy-ethyl)-piperidine-1-carboxylic Acid Benzyl Ester (190846-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / Et₃N / CH₂Cl₂ / 18 h / 23 °C

2: 84 percent / Et₃N / CH₂Cl₂ / 0.42 h / 17 °C

With triethylamine; In dichloromethane;

DOI:10.1021/jm011133d

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) → 2-(2-Methanesulfonyloxy-ethyl)-piperidine-1-carboxylic Acid Benzyl Ester (190846-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / Et₃N / CH₂Cl₂ / 18 h / 23 °C

2: 84 percent / Et₃N / CH₂Cl₂ / 0.42 h / 17 °C

With triethylamine; In dichloromethane;

DOI:10.1021/jm011133d

upstream raw materials:

methanesulfonyl chloride

2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester

2(RS)-(2-hydroxyethyl)piperidine

N-(Benzyloxycarbonyloxy)succinimide

Downstream raw materials:

N-benzyloxycarbonyl-2(RS)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine

N-[(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

N-[N-(2,2,2-trichloroethoxycarbonyl)-(R)-cyclohexylalanyl]-2(RS)-[2-(N-t-butoxycarbonyl-4-piperidinyloxy)ethyl]piperidine

N-[(R)-cyclohexylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

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