butanoic acid, 2-phenoxy-, (2R)-

Base Information

• Chemical Name: butanoic acid, 2-phenoxy-, (2R)-
• CAS No.: 19128-84-8
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol file: 19128-84-8.mol

Synonyms:

Chemical Property of butanoic acid, 2-phenoxy-, (2R)-

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butanoic acid, 2-phenoxy-, (2R)-

There total 6 articles about butanoic acid, 2-phenoxy-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-α-phenoxybutenoic acid (937025-54-2) → (R)-2-ethyl-2-phenoxyacetic acid (19128-84-8)

Guidance literature:

With (+)-TMBTP; hydrogen; triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In methanol; ethanol; dichloromethane; at 20 - 25 ℃; for 20h; under 4654.33 Torr;

DOI:10.1021/ol0488035

Reference yield:

(Z)-α-phenoxybutenoic acid (937025-54-2) → (S)-2-phenoxy-3-phenylpropanoic acid (19128-85-9) + (R)-2-ethyl-2-phenoxyacetic acid (19128-84-8)

Guidance literature:

With hydrogen; (R)-spirofluorene-bis[(4-Me-C₆H₄)2P]-[Ru(OAc)2]; In methanol; at 25 - 28 ℃; for 12h; under 76000 Torr; Title compound not separated from byproducts;

DOI:10.1002/adsc.200606065

Reference yield:

phenol (108-95-2,27073-41-2) → (R)-2-ethyl-2-phenoxyacetic acid (19128-84-8)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetonitrile / 16 h / 80 °C

2: KOH / H₂O / 20 h / 22 °C

3: Et₃N; (+)-TMBTP; H₂ / [(p-cymene)RuCl₂]2 / ethanol; methanol; CH₂Cl₂ / 20 h / 20 - 25 °C / 4654.33 Torr

With potassium hydroxide; (+)-TMBTP; hydrogen; potassium carbonate; triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In methanol; ethanol; dichloromethane; water; acetonitrile;

DOI:10.1021/ol0488035

upstream raw materials:

2-phenoxybutyric acid

(Z)-α-phenoxybutenoic acid

phenol

Downstream raw materials:

(R)-2-ethyl-2-penoxyethanol