1-Methylenespiro[4.4]nonane

Base Information

• Chemical Name: 1-Methylenespiro[4.4]nonane
• CAS No.: 19144-06-0
• Molecular Formula: C10H16
• Molecular Weight: 136.23400
• Hs Code.: 2902199090
• Mol file: 19144-06-0.mol

Synonyms:1-Methylenespiro[4.4]nonane;Spiro[4.4]nonane,1-methylene;9-methylidenespiro[4.4]nonane;

Chemical Property of 1-Methylenespiro[4.4]nonane

Chemical Property:

• PSA: 0.00000
• LogP: 3.28690

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methylenespiro[4.4]nonane

There total 7 articles about 1-Methylenespiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

spiro[4.4]nonan-1-one (14727-58-3) + Methyltriphenylphosphonium bromide (1779-49-3) → 1-Methylen-spiro<4.4>nonan (19144-06-0)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In diethyl ether; for 0.5h; Heating;

spiro[4.4]nonan-1-one; In diethyl ether; at 60 ℃; for 1.5h; Further stages.;

DOI:10.1021/jo7017558

Reference yield:

1,2-dimethylenecyclopentane (20968-70-1) → 1-Methylen-spiro<4.4>nonan (19144-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: activated Mg / tetrahydrofuran / Ambient temperature

2: tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) r.t., 10 h

With magnesium; In tetrahydrofuran;

DOI:10.1021/jo00050a036

Reference yield:

C7H10Mg + 1,3-dibromo-propane (109-64-8) → 1-Methylen-spiro<4.4>nonan (19144-06-0)

Guidance literature:

In tetrahydrofuran; Yield given; 1.) -78 deg C, 1 h, 2.) r.t., 10 h;

DOI:10.1021/jo00050a036

upstream raw materials:

spiro[4.4]nonan-1-one

Methylenetriphenylphosphorane

1,2-dimethylenecyclopentane

1,3-dibromo-propane