2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one

Base Information

• Chemical Name: 2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one
• CAS No.: 19194-52-6
• Molecular Formula: C10H11NO
• Molecular Weight: 161.20000
• Mol file: 19194-52-6.mol

Synonyms:3,3-Dimethylisoindolin-1-on;3,3-Dimethyl-isoindolin-1-on;3,3-Dimethylisoindol-1-one;3,3-Dimethylisoindolin-1-one;3,3-dimethyl-isoindolin-1-one;

Chemical Property of 2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one

Chemical Property:

• PSA: 29.10000
• LogP: 1.99390

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dihydro-3,3-dimethyl-1H-Isoindol-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one

There total 18 articles about 2,3-dihydro-3,3-diMethyl-1H-Isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(2-isopropylphenyl)-1,4,2-dioxazol-5-one → 3,3-dimethylisoindolin-1-one (19194-52-6)

Guidance literature:

With C₁₈H₂₄ClIrN₃⁽¹⁺⁾*Cl^(1-); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; at 40 ℃; for 4h;

DOI:10.1021/acs.joc.0c00157

Reference yield: 75.0%

N-(1-methyl-1-phenylethyl)picolinamide (1404616-63-2) + diethylazodicarboxylate (1972-28-7,218603-74-8) → 3,3-dimethylisoindolin-1-one (19194-52-6)

Guidance literature:

With cobalt(II) diacetate tetrahydrate; silver carbonate; Trimethylacetic acid; In 2,2,2-trifluoroethanol; at 120 ℃; for 24h; regioselective reaction;

DOI:10.1002/adsc.201700780

Reference yield: 66.0%

3,3-Dimethyl-5-(1-phenyl-1H-tetrazol-5-yloxy)-2,3dihydroisoindol-1-one (184906-32-9) → 3,3-dimethylisoindolin-1-one (19194-52-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm960243v

upstream raw materials:

3,3-Dimethyl-5-(1-phenyl-1H-tetrazol-5-yloxy)-2,3dihydroisoindol-1-one

α-methyl-α-(3-methoxyphenyl)proprionic acid

2-(3'-Methoxyphenyl)-2-methylpropionitrile

5-Hydroxy-3,3-dimethyl-2,3-dihydroisoindol-1-one