1404616-63-2

Upstream product

• 98-98-6 2-Picolinic acid 
• 585-32-0 2-phenyl-2-propylamine 
• 69157-32-0 picolinic acid 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 19194-52-6 3,3-dimethylisoindolin-1-one 
• 1443144-32-8 N-(2-(2,6-difluorophenyl)propan-2-yl)picolinamide 
• 1404616-86-9 N-(1-methyl-1-(2-(4-methoxyphenylthio)phenyl)ethyl)picolinamide 
• 1404616-87-0 N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide 

Relevant academic research and scientific papers

Copper(II) mediated C-8 amination of 1-naphthylamide derivatives with acyclic and cyclic amines

A simple and facile copper(II) mediated protocol for C-8 amination of 1-naphthylamide derivatives is reported here. Picolinamide and its derivatives were used as a bidentate directing group for the C-8 amination reaction. Various substituted naphthylamide derivatives with numerous cyclic and acyclic amines proceed in good yields under mild conditions. Air was used solely as an oxidant.

Directed amination of non-acidic arene C-H bonds by a copper-silver catalytic system

Amine meets arene: A method for direct amination of β-C(sp 2)-H bonds of benzoic acid derivatives and γ-C(sp 2)-H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2/s

Scope and limitations of auxiliary-assisted, palladium-catalyzed arylation and alkylation of sp2 and sp3 C-H bonds

The scope of palladium-catalyzed, auxiliary-assisted direct arylation and alkylation of sp2 and sp3 C-H bonds of amine and carboxylic acid derivatives has been investigated. The method employs a palladium acetate catalyst, substrate, aryl, alkyl, benzyl, or allyl halide, and inorganic base in tert-amyl alcohol or water solvent at 100-140 C. Aryl and alkyl iodides as well as benzyl and allyl bromides are competent reagents in this transformation. The picolinic acid auxiliary is used for amine γ-functionalization, and the 8-aminoquinoline auxiliary is used for carboxylic acid β-functionalization. Some optimization of base, additives, and solvent is required for achieving best results.

Copper-promoted sulfenylation of sp2 C-H bonds

An auxiliary-assisted, copper catalyzed or promoted sulfenylation of benzoic acid derivative β-C-H bonds and benzylamine derivative γ-C-H bonds has been developed. The method employs disulfide reagents, copper(II) acetate, and DMSO solvent at 90-130 °C. Application of this methodology to the direct trifluoromethylsulfenylation of C-H bonds was demonstrated.