5-ethynyl-2-Methylpyridine

Base Information

• Chemical Name: 5-ethynyl-2-Methylpyridine
• CAS No.: 1945-85-3
• Molecular Formula: C8H7N
• Molecular Weight: 117.15
• Hs Code.: 2933399090
• Mol file: 1945-85-3.mol

Synonyms:5-ethynyl-2-methyl-pyridine;2-methyl-5-pyridylacetylene;2-methyl-5-pyridylacetate;5-Aethinyl-2-methyl-pyridin;5-ethynyl-2-methylpyridine;2-methyl-5-ethynylpyridine;

Chemical Property of 5-ethynyl-2-Methylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 1.37130

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-ethynyl-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ethynyl-2-Methylpyridine

There total 9 articles about 5-ethynyl-2-Methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-methyl-4-(6-methylpyridin-3-yl)but-3-yn-2-ol (52535-35-0) → 2-methyl-5-pyridylacetylene (1945-85-3)

Guidance literature:

With potassium hydroxide; In benzene; for 3h; Reflux;

DOI:10.1002/chem.200800056

Reference yield: 63.0%

(6-methylpyridin-3-yl)trifluoromethanesulfonate (111770-91-3) + 2-methyl-but-3-yn-2-ol (115-19-5) → 2-methyl-5-pyridylacetylene (1945-85-3)

Guidance literature:

(6-methylpyridin-3-yl)trifluoromethanesulfonate; With piperidine; Tri(p-tolyl)phosphine; palladium diacetate; In 1-methyl-pyrrolidin-2-one; toluene; Inert atmosphere;

2-methyl-but-3-yn-2-ol; In 1-methyl-pyrrolidin-2-one; toluene; at 40 ℃;

With sodium hydroxide; In toluene; for 2h; Reflux;

Reference yield:

2-methyl-5-trimethylsilanylethynyl-pyridine (250252-33-6) → 2-methyl-5-pyridylacetylene (1945-85-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h;

upstream raw materials:

5-(1-chloroethenyl)-2-methylpyridine

1-(6-methyl-pyridin-3-yl)-ethanone

2-methyl-5-trimethylsilanylethynyl-pyridine

2-methyl-4-(6-methylpyridin-3-yl)but-3-yn-2-ol

Downstream raw materials:

CH₃C₅H₃NCCSn(CH₃)3

2-methyl-5-trimethylsilanylethynyl-pyridine

bis(trimethyltin)acetylene

C₆₂H₉₆N₂O₁₉

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND USES THEREOF". Paragraph 00655; 00659; 00709. . Retrieved 2015/04/22.
• 2、 Tartaggia, Stefano,Caporale, Andrea,Fontana, Francesco,Stabile, Paolo,Castellin, Andrea,De Lucchi, Ottorino. "A convenient synthesis of the key intermediate of selective COX-2 inhibitor Etoricoxib". . p. 18544 - 18549. Retrieved 2013/10/21.