Tert-butyl 2-iodo-6-methoxyphenylcarbamate

Base Information

Chemical Name:Tert-butyl 2-iodo-6-methoxyphenylcarbamate
CAS No.:194869-15-3
Molecular Formula:C12H16INO3
Molecular Weight:349.168
Hs Code.:
DSSTox Substance ID:DTXSID00444546
Wikidata:Q82262712

Synonyms:194869-15-3;tert-butyl 2-iodo-6-methoxyphenylcarbamate;tert-Butyl (2-iodo-6-methoxyphenyl)carbamate;tert-butyl N-(2-iodo-6-methoxyphenyl)carbamate;SCHEMBL729159;DTXSID00444546;QZVYQNHTMJZPLS-UHFFFAOYSA-N;Carbamic acid, (2-iodo-6-methoxyphenyl)-, 1,1-dimethylethyl ester;AKOS015890936;tert-Butyl(2-iodo-6-methoxyphenyl)carbamate;EN300-343766;Z1505691843

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Tert-butyl 2-iodo-6-methoxyphenylcarbamate

Chemical Property:

PSA：51.05000
LogP:3.66040
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:349.01749
Heavy Atom Count:17
Complexity:265

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1=C(C=CC=C1I)OC

Technology Process of Tert-butyl 2-iodo-6-methoxyphenylcarbamate

There total 7 articles about Tert-butyl 2-iodo-6-methoxyphenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 154150-18-2
tert-butyl 2-methoxyphenylcarbamate

: 194869-15-3
2-(N-tert-butoxycarbonylamino)-1-iodo-3-methoxybenzene

Guidance literature:: tert-butyl 2-methoxyphenylcarbamate; With tert.-butyl lithium; In diethyl ether; pentane; at -25 ℃; for 22h;

With 1-chloro-2-iodoethane; In diethyl ether; pentane; at 20 ℃; for 16h; Further stages.;
DOI:10.1021/jo025615o

Reference yield: 46.0%

: 194869-15-3
2-(N-tert-butoxycarbonylamino)-1-iodo-3-methoxybenzene

Guidance literature:

Reference yield:

: 90-04-0
2-methoxy-phenylamine

: 194869-15-3
2-(N-tert-butoxycarbonylamino)-1-iodo-3-methoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / tetrahydrofuran / Heating

2.1: t-BuLi / diethyl ether; pentane / 3 h / -20 °C

2.2: 47 percent / iodine / diethyl ether; pentane / -90 - 20 °C

With tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane;
DOI:10.1002/anie.200604038