2,3,4-Trimethoxy-6-methylbenzaldehyde

Base Information

• Chemical Name: 2,3,4-Trimethoxy-6-methylbenzaldehyde
• CAS No.: 22383-85-3
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• European Community (EC) Number: 244-946-4
• DSSTox Substance ID: DTXSID20176913
• Nikkaji Number: J30.712B
• Wikidata: Q72513778
• Mol file: 22383-85-3.mol

Synonyms:2,3,4-Trimethoxy-6-methylbenzaldehyde;22383-85-3;22838-85-3;EINECS 244-946-4;Benzaldehyde, 2,3,4-trimethoxy-6-methyl-;6-Methyl-2,3,4-trimethoxybenzaldehyde;SCHEMBL677316;DTXSID20176913;MFCD00016598;AKOS015890454;4-(Aminomethyl)-N-hydroxybenzimidamide;AS-76439;CS-0153355;FT-0638219;D81933;A816174;W-107476;1-(4-chlorophenyl)sulfonyl-3-cyclohex-2-en-1-yl-urea

Chemical Property of 2,3,4-Trimethoxy-6-methylbenzaldehyde

Chemical Property:

• Vapor Pressure: 0.000101mmHg at 25°C
• Melting Point: 60-61 °C
• Refractive Index: 1.523
• Boiling Point: 337.942 °C at 760 mmHg
• Flash Point: 149.439 °C
• PSA: 44.76000
• Density: 1.11 g/cm³
• LogP: 1.83330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 210.08920892
• Heavy Atom Count: 15
• Complexity: 207

Purity/Quality:

99% ^*data from raw suppliers

2,3,4-Trimethoxy-6-methylbenzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1C=O)OC)OC)OC
• Uses: 2,3,4-Trimethoxy-6-methylbenzaldehyde is a reagent used in the preparation of pyrroloindole derivatives which has antitumor activity.

Technology Process of 2,3,4-Trimethoxy-6-methylbenzaldehyde

There total 7 articles about 2,3,4-Trimethoxy-6-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4,5-trimethoxytoluene (6443-69-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,3,4-trimethoxy-6-methylbenzaldehyde (22383-85-3)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/jacs.6b06899

Reference yield: 95.0%

Dichloromethyl methyl ether (4885-02-3) + 3,4,5-trimethoxytoluene (6443-69-2) → 2,3,4-trimethoxy-6-methylbenzaldehyde (22383-85-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1080/00397910701771066

Reference yield: 75.0%

C11H14O4 → 2,3,4-trimethoxy-6-methylbenzaldehyde (22383-85-3)

Guidance literature:

With sodium methylate; In methanol; at 70 ℃;

DOI:10.2533/chimia.2018.870

upstream raw materials:

3,4,5-trimethoxytoluene

N,N-dimethyl-formamide

N-methyl-N-phenylformamide

N-formyldiethylamine

Downstream raw materials:

2-hydroxy-3,4-dimethoxy-6-methylbenzaldehyde

2,3,4-trihydroxy-6-methylbenzaldehyde

2,3-Dimethoxy-5-methyl-1,4-benzoquinone

2,3,4-trimethoxy-6-methylphenol