4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carbaldehyde

Base Information

• Chemical Name: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carbaldehyde
• CAS No.: 197237-97-1
• Molecular Formula: C8H9NOS
• Molecular Weight: 167.232
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00474323
• Mol file: 197237-97-1.mol

Synonyms:4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbaldehyde;197237-97-1;4H,5H,6H,7H-thieno[3,2-c]pyridine-2-carbaldehyde;SCHEMBL2559315;DTXSID00474323;AKOS015856643;A4314;CS-0271926;FT-0682577;EN300-2979090

Chemical Property of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 340.907oC at 760 mmHg
• Flash Point: 159.975oC
• PSA: 57.34000
• Density: 1.253g/cm3
• LogP: 1.53510
• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 167.04048508
• Heavy Atom Count: 11
• Complexity: 162

Purity/Quality:

97% ^*data from raw suppliers

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCC2=C1SC(=C2)C=O

Technology Process of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carbaldehyde

There total 1 articles about 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(formyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate (165947-55-7) → 2-(formyl)-6,7-dihydrothieno[3,2-c]-5(4H)-pyridine (197237-97-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane;

Reference yield: 89.0%

2-(formyl)-6,7-dihydrothieno[3,2-c]-5(4H)-pyridine (197237-97-1) + phenylacetyl chloride (103-80-0) → 2-formyl[5-(phenylacetyl)-4,5,6,7-tetrahydrothieno][3,2-c]pyridine (623565-04-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield: 35.0%

2-(formyl)-6,7-dihydrothieno[3,2-c]-5(4H)-pyridine (197237-97-1) + p-methoxybenzyl chloride (824-94-2) → 2-formyl-[5-(4-methoxybenzyl)-4,5,6,7-tetrahydrothieno][3,2-c]pyridine (623564-32-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

upstream raw materials:

tert-butyl 2-(formyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

Downstream raw materials:

2-formyl-[5-(4-methoxybenzyl)-4,5,6,7-tetrahydrothieno][3,2-c]pyridine

2-formyl[5-(phenylacetyl)-4,5,6,7-tetrahydrothieno][3,2-c]pyridine