Benzenemethanol, a-methyl-4-nitro-, acetate (ester)

Base Information

• Chemical Name: Benzenemethanol, a-methyl-4-nitro-, acetate (ester)
• CAS No.: 19759-27-4
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.202
• Mol file: 19759-27-4.mol

Synonyms:

Chemical Property of Benzenemethanol, a-methyl-4-nitro-, acetate (ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, a-methyl-4-nitro-, acetate (ester)

There total 28 articles about Benzenemethanol, a-methyl-4-nitro-, acetate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-nitrophenyl)-1-(acetyloxy)ethylene (22391-01-1) → (1R)-1-(4-nitrophenyl)ethyl acetate (19759-27-4,73104-87-7,104013-24-3)

Guidance literature:

With Ph(COD)2BF₄; hydrogen; (S)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a:3,4-a']-dinaphthalen-4-yl)piperidine; In dichloromethane; at 20 ℃; for 16h; under 3750.3 Torr;

DOI:10.1021/ol051559c

Reference yield: 98.0%

1-[4-nitrophenyl]-1-ethanol (6531-13-1) + acetic anhydride (108-24-7) → 4-(α-acetoxyethyl)-1-nitrobenzene (19759-27-4)

Guidance literature:

With silver trifluoromethanesulfonate; at 60 ℃; for 0.025h; neat (no solvent);

DOI:10.1055/s-0030-1259999

Reference yield: 97.0%

Isopropenyl acetate (108-22-5) + 1-[4-nitrophenyl]-1-ethanol (6531-13-1) → (1R)-1-(4-nitrophenyl)ethyl acetate (19759-27-4,73104-87-7,104013-24-3)

Guidance literature:

With Candida antarctica lipase B; potassium tert-butylate; sodium carbonate; [chlorodicarbonyl(η-pentaphenylcyclopentadienyl)]Ru(II); In toluene; at 20 ℃; for 20h;

DOI:10.1002/anie.200461416

upstream raw materials:

1-Phenylethanol

acetic anhydride

Isopropenyl acetate

1-[4-nitrophenyl]-1-ethanol

Downstream raw materials:

1-[4-nitrophenyl]-1-ethanol

(1R)-1-(4-nitrophenyl)ethanol

(S)-1-(4-nitrophenyl)ethyl acetate

(1R)-1-(4-nitrophenyl)ethyl acetate