Technology Process of 1,3-Piperidinedicarboxylic acid, 4-phenyl-, 1-(1,1-dimethylethyl) ester,
(3S,4S)-
There total 9 articles about 1,3-Piperidinedicarboxylic acid, 4-phenyl-, 1-(1,1-dimethylethyl) ester,
(3S,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(tert-butoxycarbonyl)-4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid;
With
hydrogen; triethylamine;
(1R,1’R,2S,2’S)-2,2’-di-tert-butyl-2,3,2’,3’-tetrahydro-1H,1‘H-(1,1‘)biisophosphindolyl; [Ru(OAc)2(COD)];
In
methanol;
at 60 - 80 ℃;
for 68h;
under 30003 Torr;
With
sodium hydroxide;
In
methanol; tert-butyl methyl ether; water;
With
hydrogenchloride;
In
water;
at 0 ℃;
pH=1;
Product distribution / selectivity;
- Guidance literature:
-
1-(tert-butoxycarbonyl)-4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid;
With
hydrogen; triethylamine;
[Ru(OAc)2((S)-(6-MeO-2-Naphthyl)-MeOBIPHEP)];
In
tetrahydrofuran;
at 80 ℃;
for 65h;
under 30003 Torr;
With
sodium hydroxide;
In
methanol; tert-butyl methyl ether; water;
With
hydrogenchloride;
In
water;
at 0 ℃;
pH=1;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Pd(OAc)2, NMP / -15 - 0 °C
2: 99 percent / H2 / 10percent Pd/C / ethanol
3: aq. LiOH / tetrahydrofuran; methanol
With
1-methyl-pyrrolidin-2-one; palladium diacetate; lithium hydroxide; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1016/S0960-894X(98)00451-X
