2-Phenyl-4-tert-butylthiazole

Base Information

• Chemical Name: 2-Phenyl-4-tert-butylthiazole
• CAS No.: 19960-63-5
• Molecular Formula: C13H15NS
• Molecular Weight: 217.33000
• Mol file: 19960-63-5.mol

Synonyms:4-tert-Butyl-2-phenyl-thiazole;2-Phenyl-4-tert.-butylthiazol;4-t-Butyl-2-phenylthiazol;4-tert-Butyl-2-phenyl-thiazol;4-t-Butyl-2-phenyl-thiazol;

Chemical Property of 2-Phenyl-4-tert-butylthiazole

Chemical Property:

• Boiling Point: 158 - 159 °C (15 mmHg)
• PSA: 41.13000
• LogP: 4.10760

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyl-4-tert-butylthiazole

There total 3 articles about 2-Phenyl-4-tert-butylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,3-dimethyl-1-(tosyloxy)butan-2-one (7257-96-7) + benzenecarbothioamide (2227-79-4) → 4-tert-butyl-2-phenylthiazole (19960-63-5)

Guidance literature:

With β‐cyclodextrin; In water; acetone; at 20 ℃; for 2.5h;

DOI:10.1080/00397910701575913

Reference yield:

S-(3,3-dimethyl-1-butynyl)thiobenzimidonium tetrafluoroborate → 4-tert-butyl-2-phenylthiazole (19960-63-5)

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1002/anie.200502438

Reference yield:

→ 4-tert-butyl-2-phenylthiazole (19960-63-5)

Guidance literature:

With sulfur;

upstream raw materials:

3,3-dimethyl-1-(tosyloxy)butan-2-one

benzenecarbothioamide

Refernces

• 1、 Kumar, V. Pavan,Narender,Sridhar,Nageswar,Rao, K. Rama. "Synthesis of thiazoles and aminothiazoles from β-keto tosylates under supramolecular catalysis in the presence of β-cyclodextrin in water". . p. 4331 - 4336. Retrieved 2008/03/13.