2(5H)-Furanone, 3,4-dichloro-5-(2-oxo-2-phenylethyl)-

Base Information

• Chemical Name: 2(5H)-Furanone, 3,4-dichloro-5-(2-oxo-2-phenylethyl)-
• CAS No.: 20030-09-5
• Molecular Formula: C12H8Cl2O3
• Molecular Weight: 271.1
• DSSTox Substance ID: DTXSID40384997
• Nikkaji Number: J2.151.814J
• Mol file: 20030-09-5.mol

Synonyms:3,4-dichloro-5-(2-oxo-2-phenylethyl)-2(5H)-furanone;20030-09-5;2(5H)-Furanone, 3,4-dichloro-5-(2-oxo-2-phenylethyl)-;SCHEMBL5426096;DTXSID40384997;AKOS024344029;3,4-Dichloro-5-(beta-oxophenethyl)-2,5-dihydrofuran-2-one

Chemical Property of 2(5H)-Furanone, 3,4-dichloro-5-(2-oxo-2-phenylethyl)-

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 269.9850495
• Heavy Atom Count: 17
• Complexity: 370

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)CC2C(=C(C(=O)O2)Cl)Cl

Technology Process of 2(5H)-Furanone, 3,4-dichloro-5-(2-oxo-2-phenylethyl)-

There total 3 articles about 2(5H)-Furanone, 3,4-dichloro-5-(2-oxo-2-phenylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

Mucochloric acid (766-40-5) + acetophenone (98-86-2) → 3,4-dichloro-5-(2-oxo-2-phenethyl)-5H-furan-2-one (20030-09-5)

Guidance literature:

Mucochloric acid; acetophenone; With sodium hydroxide; In methanol; water; at 0 - 20 ℃; for 3h;

With hydrogenchloride; In methanol; water; at 0 ℃; for 0.75h;

Reference yield:

Mucochloric acid (766-40-5) + 1-styrenyloxytrimethylsilane (13735-81-4) → 3,4-dichloro-5-(4-oxo-2,4-diphenyl-but-2-enyl)-5H-furan-2-one + 3,4-dichloro-5-(2-oxo-2-phenethyl)-5H-furan-2-one (20030-09-5)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In 1,2-dimethoxyethane; at -20 - 20 ℃; for 6h; Further Variations:; Solvents; Product distribution;

DOI:10.1016/j.tetlet.2005.01.147

Reference yield:

mucochloric acid (87-56-9) + acetophenone (98-86-2) → 3,4-dichloro-5-(2-oxo-2-phenethyl)-5H-furan-2-one (20030-09-5)

Guidance literature:

With sodium hydroxide; durch Ansaeuern der entstandenen α.β-Dichlor-γ-phenacal-crotonsaeure;

upstream raw materials:

mucochloric acid

acetophenone

Mucochloric acid

1-styrenyloxytrimethylsilane

Downstream raw materials:

3-Chloro-5-(2-oxo-2-phenyl-ethyl)-4-phenylamino-5H-furan-2-one

3,4-dichloro-5-(2-((Z)-2-(2,4-dinitrophenyl)hydrazono)-2-phenylethyl)furan-2(5H)-one