(2-chlorophenoxy)acetyl chloride

Base Information

• Chemical Name: (2-chlorophenoxy)acetyl chloride
• CAS No.: 20143-41-3
• Molecular Formula: C8H6Cl2O2
• Molecular Weight: 205.04
• Hs Code.: 2918990090
• Mol file: 20143-41-3.mol

Synonyms:(2-Chlor-phenoxy)-essigsaeure-hydrazid;2-(2-chlorophenoxy)acetic acid hydrazide;2-chlorophenoxyacetyl chloride;2-(2-chlorophenoxy)acetyl chloride;2-Chlorophenoxyacetylhydrazine;(2-Chlor-phenoxy)-acetylchlorid;(2-chlorophenoxy)acetic acid hydrazide;o-chlorophenoxyacetyl chloride;

Chemical Property of (2-chlorophenoxy)acetyl chloride

Chemical Property:

• PSA: 26.30000
• LogP: 2.48420

Purity/Quality:

98%min ^*data from raw suppliers

(2-chlorophenoxy)acetylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-chlorophenoxy)acetyl chloride

There total 6 articles about (2-chlorophenoxy)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-chlorophenoxy)acetic acid (614-61-9) → (2-chloro-phenoxy)-acetyl chloride (20143-41-3)

Guidance literature:

With thionyl chloride; at 60 ℃;

Reference yield:

2-monochlorophenol (95-57-8) → (2-chloro-phenoxy)-acetyl chloride (20143-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 33percent aq. NaOH / 1 h / Heating

2: SOCl₂ / CHCl₃ / 6 h / Heating

With sodium hydroxide; thionyl chloride; In chloroform;

Reference yield:

tert-butyl 2-(2-chlorophenoxy)acetate (36304-23-1) → (2-chloro-phenoxy)-acetyl chloride (20143-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1 h / 20 °C

2: thionyl chloride / dichloromethane / 4 h / Reflux

With thionyl chloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1111/bph.14220

upstream raw materials:

(2-chlorophenoxy)acetic acid

2-monochlorophenol

sodium 2-chlorophenoxide

tert-butyl 2-(2-chlorophenoxy)acetate

Downstream raw materials:

2-(2-chloro-phenoxy)-N-(5-phenyl-[1,3,4]thiadiazol-2-yl)-acetamide

1-Aziridin-1-yl-2-(2-chloro-phenoxy)-ethanone

2-(2-Chloro-phenoxy)-N-(4-hydroxy-2-oxo-2H-chromen-3-yl)-acetamide

N-(6-Chloro-4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(2-chloro-phenoxy)-acetamide

Refernces

• 1、 Obushak, M. D.,Pokhodylo, N. T.,Shyyka, O. Ya.. "A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group". . p. 802 - 812. Retrieved 2020/07/03.
• 2、 Lei, Kang,Li, Pan,Yang, Xue-Fang,Wang, Shi-Ben,Wang, Xue-Kun,Hua, Xue-Wen,Sun, Bin,Ji, Lu-Sha,Xu, Xiao-Hua. "Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action". . p. 10489 - 10497. Retrieved 2019/10/02.