Technology Process of (5S)-5-Phenyl-3,5-dimethylimidazolidine-2,4-dione
There total 14 articles about (5S)-5-Phenyl-3,5-dimethylimidazolidine-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide / water; tetrahydrofuran / 20 h / 45 °C
2: diisopropylamine; n-butyllithium; lithium diisopropyl amide; lithium chloride / tetrahydrofuran / 3 h / -78 - 20 °C
With
n-butyllithium; diisopropylamine; lithium chloride; lithium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; water;
DOI:10.1002/anie.201502569
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium hexamethylsilazane / tetrahydrofuran / -78 - -40 °C
2: sodium nitrite; acetic acid; hydrogenchloride / 3 h / 110 °C
With
hydrogenchloride; potassium hexamethylsilazane; acetic acid; sodium nitrite;
In
tetrahydrofuran;
DOI:10.1039/c8sc05263h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / acetonitrile / 20 h / Reflux
2.1: lithium hydroxide / water; tetrahydrofuran / 20 h / 45 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; water / 19 h / 0 - 20 °C
4.1: diisopropylamine; n-butyllithium; lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
4.2: 3 h / -78 - 20 °C
With
n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;
DOI:10.1002/anie.201502569