Formamide, N-[5-(2R)-oxiranyl-2-(phenylmethoxy)phenyl]-

Base Information

Chemical Name:Formamide, N-[5-(2R)-oxiranyl-2-(phenylmethoxy)phenyl]-
CAS No.:201677-57-8
Molecular Formula:C16H15NO3
Molecular Weight:269.3
Hs Code.:
Mol file:201677-57-8.mol

Synonyms:(R)-[4-(benzyloxy)-3-(formamino)phenyl]oxirane;N-(2-benzyloxy-5-(R)-oxiranylphenyl)formamide;[2-(BENZYLOXY)-5-[(2R)-OXIRAN-2-YL] PHENYLFORMAMIDE];(R)-N-(2-(benzyloxy)-5-(oxiran-2-yl)phenyl)formamide;{5-[(2R)-2-oxiranyl]-2-[(phenylmethyl)oxy]phenyl}formamide;2-(benzyloxy)-5-[(2R)-oxiran-2-yl]phenylformamide;

Suppliers and Price of Formamide, N-[5-(2R)-oxiranyl-2-(phenylmethoxy)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 9 raw suppliers

Chemical Property of Formamide, N-[5-(2R)-oxiranyl-2-(phenylmethoxy)phenyl]-

Chemical Property:

Melting Point:79 - 80 °C
PSA：50.86000
LogP:3.61410

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Formamide, N-[5-(2R)-oxiranyl-2-(phenylmethoxy)phenyl]-

There total 8 articles about Formamide, N-[5-(2R)-oxiranyl-2-(phenylmethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 201677-59-0
N-[5-((1R)-2-bromo-1-hydroxyethyl)-2-(phenylmethoxy)phenyl]carboxamide

: 201677-57-8
N-[2-(benzyloxy)-5-[(2R)-oxiran-2-yl]phenyl]formamide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;
DOI:10.1002/chir.20728

Reference yield:

: 188690-82-6
(R)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol

: 201677-57-8
N-[2-(benzyloxy)-5-[(2R)-oxiran-2-yl]phenyl]formamide

Guidance literature:: Multi-step reaction with 3 steps

1: platinum on carbon; dimethylsulfide; hydrogen / tetrahydrofuran / 12 h / 40 °C / 25858.1 Torr

2: acetic anhydride / tetrahydrofuran / 1 h / 10 - 20 °C

3: potassium carbonate / tetrahydrofuran; methanol / 2 h / 20 °C

With dimethylsulfide; platinum on carbon; hydrogen; acetic anhydride; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2012.01.013

Reference yield:

: 64-18-6
formic acid

: 333796-54-6
(1R)-1-[3-amino-4-(phenylmethoxy)phenyl]-2-bromoethan-1-ol

: 201677-57-8
N-[2-(benzyloxy)-5-[(2R)-oxiran-2-yl]phenyl]formamide

Guidance literature:: formic acid; With acetic anhydride; at 0 - 5 ℃; Inert atmosphere;

(1R)-1-[3-amino-4-(phenylmethoxy)phenyl]-2-bromoethan-1-ol; In tetrahydrofuran; at 0 - 5 ℃; for 1h; Inert atmosphere;