2,6-Dimethoxy-5-nitropyrimidin-4-amine

Base Information

• Chemical Name: 2,6-Dimethoxy-5-nitropyrimidin-4-amine
• CAS No.: 73978-74-2
• Molecular Formula: C6H8N4O4
• Molecular Weight: 200.1521
• NSC Number: 45770
• DSSTox Substance ID: DTXSID10286434
• Nikkaji Number: J1.031.656A
• Wikidata: Q82022154
• Mol file: 73978-74-2.mol

Synonyms:2,6-dimethoxy-5-nitropyrimidin-4-amine;73978-74-2;4-amino-2,6-dimethoxy-5-nitropyrimidine;NSC45770;SCHEMBL10414626;DTXSID10286434;AEFIKWJHKJRACJ-UHFFFAOYSA-N;NSC-45770;STL488850;AKOS002303143;2,6-Dimethoxy-5-nitro-4-pyrimidinamine

Chemical Property of 2,6-Dimethoxy-5-nitropyrimidin-4-amine

Chemical Property:

• Vapor Pressure: 3.79E-08mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 445.9 °C at 760 mmHg
• Flash Point: 223.5 °C
• PSA: 116.08000
• Density: 1.45 g/cm³
• LogP: 1.08860
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 200.05455475
• Heavy Atom Count: 14
• Complexity: 209

Purity/Quality:

2,6-DIMETHOXY-5-NITRO-4-PYRIMIDINAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=NC(=C1[N+](=O)[O-])N)OC

Technology Process of 2,6-Dimethoxy-5-nitropyrimidin-4-amine

There total 5 articles about 2,6-Dimethoxy-5-nitropyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chloro-2,6-dimethoxy-5-nitropyrimidine (60331-03-5) → 6-amino-2,4-dimethoxy-5-nitropyrimidine (73978-74-2)

Guidance literature:

With ammonium acetate; In tetrahydrofuran; for 5h; Heating;

DOI:10.3987/com-98-8375

Reference yield: 52.0%

2,6-dimethoxypyrimidin-4-amine (3289-50-7) → 6-amino-2,4-dimethoxy-5-nitropyrimidine (73978-74-2)

Guidance literature:

With nitric acid; In sulfuric acid; at 0 - 10 ℃;

Reference yield:

2,6-dichloro-5-nitropyrimidin-4-amine (31221-68-8) + sodium methylate (124-41-4) → 6-amino-2,4-dimethoxy-5-nitropyrimidine (73978-74-2)

Guidance literature:

With methanol;

DOI:10.1021/ja01649a022

upstream raw materials:

2,6-dichloro-5-nitropyrimidin-4-amine

sodium methylate

2,6-dimethoxypyrimidin-4-amine

4-chloro-2,6-dimethoxy-5-nitropyrimidine

Downstream raw materials:

2,6-dimethoxy-7(9)H-purine

5,6-Diamino-2,4-dimethoxypyrimidine

2,4-Dimethoxy-7-oxo-7,8-dihydropteridin

2,4-Dimethoxy-6-methyl-7-oxo-7,8-dihydropteridin