H-Gly-Gly-NH2

Base Information

• Chemical Name: H-Gly-Gly-NH2
• CAS No.: 20238-94-2
• Molecular Formula: C4H9N3O2
• Molecular Weight: 131.134
• Mol file: 20238-94-2.mol

Synonyms:Glycinamide,glycyl;Glycyl=>glycin-amid;N-glycyl-glycine amide;glycylglycine amide;glycylglycyl amide;glycylglycinamide;Gly-Gly-NH2;N-Glycyl-glycin-amid;H-Gly-Gly-NH2;

Chemical Property of H-Gly-Gly-NH2

Chemical Property:

• PSA: 102.69000
• LogP: 0.23690

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-N-(2-amino-2-oxoethyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-Gly-Gly-NH2

There total 8 articles about H-Gly-Gly-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ glycylglycinamide (20238-94-2)

Guidance literature:

With ethanol; ammonia; at 0 ℃;

Reference yield:

Z-glycylglycinamide (6422-35-1) → glycylglycinamide (20238-94-2)

Guidance literature:

With hydrogen bromide; In acetic acid;

DOI:10.1515/bchm2.1963.332.1.38

Reference yield:

→ glycylglycinamide (20238-94-2)

Guidance literature:

With methanol; palladium; acetic acid; Hydrogenolyse;

upstream raw materials:

Z-glycylglycinamide

<<(benzyloxycarbonyl)glycyl>amino>acetonitrile

Z-Gly-OTcp

H-Gly-NH₂

Downstream raw materials:

glycylglycine

glycine

H-Gly-NH₂

Refernces

Analogs of oxytocin containing leucinamide and glycylglycinamide in place of glycinamide.

10.1246/bcsj.41.2772

The research aimed to synthesize and test two analogs of oxytocin, a hormone known for its role in childbirth and social bonding. The analogs, [9-leucine]-oxytocin and oxytocinoyl-glycinamide, were created by replacing the glycinamide residue at position 9 in oxytocin with leucinamide and glycylglycinamide, respectively. The study's purpose was to explore the structure-activity relationships in oxytocin and to understand the impact of these modifications on the hormone's pharmacological properties. The researchers used a variety of chemicals in their synthesis process, including benzyloxycarbonyl-tripeptide azide, hexa- or heptapeptide amide, and various protecting groups such as benzyloxycarbonyl and benzyl groups, which were later removed using sodium in liquid ammonia or anhydrous hydrogen fluoride. The synthesized analogs were then oxidized and tested for their oxytocic potency, with [9-leucine]-oxytocin showing approximately 8% potency and oxytocinoyl-glycinamide showing 0.5% potency compared to the natural oxytocin. The findings suggest that the replacement of glycine with bulkier leucine did not significantly reduce the biological activity, which is significant for understanding the structure-function relationship of the oxytocin molecule.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 20238-94-2 H-Gly-Gly-NH2

Send

Send

Metric Ton KG G Pound L ML

Send

Send