6422-35-1

Usage

Uses

Used in Enzymatic Assays:
Z-GLY-GLY-NH2 is used as a substrate in enzymatic assays for the study of enzyme activity and specificity. Its simple structure and the presence of a protective group make it an ideal candidate for these assays, allowing researchers to monitor enzymatic reactions and understand the mechanisms of enzyme-catalyzed processes.
Used in Peptide Synthesis:
In the field of peptide synthesis, Z-GLY-GLY-NH2 serves as a building block for the construction of larger peptides and proteins. The protective group "Z" ensures that the dipeptide remains stable during the synthesis process, preventing unwanted side reactions and facilitating the formation of the desired peptide sequences.
Used in Pharmaceutical Development:
Z-GLY-GLY-NH2 is utilized in the development of new pharmaceuticals, particularly in the design and synthesis of peptide-based drugs. Its properties and reactivity make it a versatile component in the creation of therapeutic agents with specific biological activities.
Used in Research and Development:
In the research and development industry, Z-GLY-GLY-NH2 is employed as a model compound for studying the fundamental aspects of peptide chemistry, enzymatic reactions, and protein folding. Its use in these studies contributes to the advancement of knowledge in biochemistry and molecular biology.
Used in Biochemical Education:
Z-GLY-GLY-NH2 is also used as an educational tool in biochemical courses and laboratories, where students can learn about peptide synthesis, enzyme kinetics, and the properties of amino acids and dipeptides through hands-on experiments and theoretical studies.

InChI:InChI=1/C12H15N3O4/c13-10(16)6-14-11(17)7-15-12(18)19-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H2,13,16)(H,14,17)(H,15,18)

Upstream product

• 3005-87-6 Z-Gly-Gly-OEt 
• 501-53-1 benzyl chloroformate 
• 3479-49-0 glycylglycine amide hydrobromide 
• 1668-10-6 glycinamide hydrochloride 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 598-41-4 H-Gly-NH₂ 
• 2566-19-0 CbzGlyGly 
• 77280-61-6 {(2-Benzyloxycarbonylamino-acetyl)-[cyclohexylcarbamoyl-(9H-fluoren-9-yl)-methyl]-amino}-acetic acid methyl ester 

Downstream Products

• 1434589-24-8 C₂₆H₂₈N₃O₆P 
• 20238-94-2 glycylglycinamide 

Relevant academic research and scientific papers

Direct synthesis of phosphinopeptides containing C-terminal α-aminoalkylphosphinic acids

A series of phosphinopeptides containing C-terminal α- aminoalkylphosphinic acids were prepared in good yields directly in one-pot reactions of 2-(N-benzoxycarbonylamino)alkanamides/peptide amides, aldehydes, and aryldichlorophosphines, followed by hydrolysis. In the current method, the peptide bond was formed in a Mannichtype reaction. Springer-Verlag 2010.

Bromelain catalyzed synthesis of peptides in organic solvent

For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz-Gly-L-Leu-OMe in 85% yield. The precursor of aspartame (Cbz-L-Asp-L-Phe-OMe) and other dipeptides were also synthesized by this method.

Synthesis and biological evaluation of analogues of the antibiotic pantocin B

Strains of the bacteria Erwinia herbicola produce antibiotics that effectively control E. amylovora, the bacterial pathogen responsible for the plant disease fire blight. Pantocin B was the first of these antibiotics to be characterized, and a flexible sy

Anticonvulsant drugs and pharmaceutical compositions thereof

According to the present invention, anticonvulsant compounds N-acetyl,N'-benzylglycinamide and N-benzyloxycarbonylglycinamide-Z-glycinamide are disclosed. The present invention also discloses an anticonvulsant pharmaceutical composition comprising an effe

Activation of carboxylic acids by pyrocarbonates. Application of di-tert-butyl pyrocarbonate as condensing reagent in the synthesis of amides of protected amino acids and peptides

Amides formation from protected amino acids and peptides was achieved in an easy and convenient one-pot procedure using di-tert-butyl pyrocarbonate as activating agent in the presence of pyridine and ammonium hydrogencarbonate. The method gave good yields and did not induce racemization during the amidation of urethane protected amino acids.

Aldehyde components for use in four-component condensation ("4CC") Ugi reaction peptide synthesis

The use of 9-formylfluorene as the aldehyde component in four-component condensation (4CC) fragment strategy peptide synthesis has been investigated in the synthesis of model dipeptides.