8-Hydroxyoctanoic acid methyl ester

Base Information

• Chemical Name: 8-Hydroxyoctanoic acid methyl ester
• CAS No.: 20257-95-8
• Molecular Formula: C9H18O3
• Molecular Weight: 174.24
• Hs Code.: 2918199090
• Mol file: 20257-95-8.mol

Synonyms:8-Hydroxy-octansaeure-methylester;8-hydroxyoctanoic acid methyl ester;Methyl-8-hydroxyoctanoate;Octanoic acid,8-hydroxy-,methyl ester;

Chemical Property of 8-Hydroxyoctanoic acid methyl ester

Chemical Property:

• Boiling Point: 239.4±23.0 °C(Predicted)
• PKA: 15.18±0.10(Predicted)
• PSA: 46.53000
• Density: 0.978±0.06 g/cm3(Predicted)
• LogP: 1.49230

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Hydroxyoctanoic acid methyl ester

There total 7 articles about 8-Hydroxyoctanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(E)-8-oxooct-2-enoic acid methyl ester (96293-27-5) → 8-hydroxyoctanoic acid methyl ester (20257-95-8) + methyl 8-oxooctanoate (3884-92-2)

Guidance literature:

With magnesium; mercury dichloride; In methanol; at -23 ℃; for 2h;

DOI:10.1021/jo00085a036

Reference yield: 38.55%

diazomethane (186581-53-3,908094-01-9,334-88-3) + methyl linolenate (301-00-8) → 8-hydroxyoctanoic acid methyl ester (20257-95-8) + hexanedioic acid dimethyl ester (627-93-0) + Dimethyl azelate (1732-10-1) + dimethyl 1,7-heptanedioate (1732-08-7) + dimethyl subarate (1732-09-8) + methyl 7-hydroxyheptanoate (14565-11-8)

Guidance literature:

With sodium hydroxide; reflux; water; dihydrogen peroxide; ozone; Product distribution; further conditions;

DOI:10.1007/BF00811471

Reference yield:

methanol (67-56-1) + 3β-O-(8-hydroxyoctanoyl)-12-oleanene (1221592-92-2) → 8-hydroxyoctanoic acid methyl ester (20257-95-8) + beta-amyrin (559-70-6)

Guidance literature:

With hydrogenchloride; In water; for 18h; Reflux;

DOI:10.1021/jf9043524

upstream raw materials:

diazomethane

methyl linolenate

methanol

(E)-8-oxooct-2-enoic acid methyl ester

Downstream raw materials:

methyl 8-oxooctanoate

8-(4-Methoxy-phenoxy)-octanoic acid methyl ester

methyl 8-hydroxyoctanoate tosylate

methyl 8-bromooctanoate