9H-Purin-6-aMine, 2-chloro-N-[(4-Methoxyphenyl)Methyl]-9-(1-Methylethyl)-

Base Information

• Chemical Name: 9H-Purin-6-aMine, 2-chloro-N-[(4-Methoxyphenyl)Methyl]-9-(1-Methylethyl)-
• CAS No.: 203436-13-9
• Molecular Formula: C16H18ClN5O
• Molecular Weight: 331.805
• Mol file: 203436-13-9.mol

Synonyms:2-chloro-6-((4-methoxybenzyl)amino)-9-isopropylpurine;2-chloro-6-(4-methoxybenzylamino)-9-isopropylpurine;2-chloro-6-[(4-methoxybenzyl)amino]-9-(2-propyl)purine;2-chloro-9-isopropyl-N-(4-methoxybenzyl)-9H-purin-6-amine;

Chemical Property of 9H-Purin-6-aMine, 2-chloro-N-[(4-Methoxyphenyl)Methyl]-9-(1-Methylethyl)-

Chemical Property:

• Boiling Point: 483.1±50.0 °C(Predicted)
• PKA: 0.39±0.10(Predicted)
• PSA: 64.86000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 3.75430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Chloro-9-isopropyl-N-(4-methoxybenzyl)-9H-purin-6-amine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9H-Purin-6-aMine, 2-chloro-N-[(4-Methoxyphenyl)Methyl]-9-(1-Methylethyl)-

There total 8 articles about 9H-Purin-6-aMine, 2-chloro-N-[(4-Methoxyphenyl)Methyl]-9-(1-Methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-benzylamine (2393-23-9) + 2,6-dichloro-9-isopropyl-9H-purine (203436-45-7) → (2-chloro-9-isopropyl-9H-purin-6-yl)-(4-methoxybenzyl)-amine (203436-13-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 110 ℃;

DOI:10.3390/molecules20046808

Reference yield:

2-iodo-propane (75-30-9) + isopropyl purine + 2-chloro-N-(4-methoxybenzyl)-9H-purin-6-amine (203436-09-3) → (2-chloro-9-isopropyl-9H-purin-6-yl)-(4-methoxybenzyl)-amine (203436-13-9)

Guidance literature:

In water; N,N-dimethyl-formamide;

Reference yield:

2,6 dichloropurine (5451-40-1) → (2-chloro-9-isopropyl-9H-purin-6-yl)-(4-methoxybenzyl)-amine (203436-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: butan-1-ol / Heating

2: NaH / dimethylformamide

With sodium hydride; In N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1016/S0960-894X(97)10076-2

upstream raw materials:

2-chloro-N-(4-methoxybenzyl)-9H-purin-6-amine

4-methoxy-benzylamine

2,6 dichloropurine

2-iodo-propane

Downstream raw materials:

Cdk2 inhibitor III

C₂₀H₂₇N₇O