2,3-Dimethoxy-9H-fluoren-9-one

Base Information

• Chemical Name: 2,3-Dimethoxy-9H-fluoren-9-one
• CAS No.: 2041-27-2
• Molecular Formula: C15H12O3
• Molecular Weight: 240.25400
• Hs Code.: 2914509090
• DSSTox Substance ID: DTXSID00452222
• Nikkaji Number: J80.371E
• Wikidata: Q82272708
• Mol file: 2041-27-2.mol

Synonyms:2,3-Dimethoxy-9H-fluoren-9-one;2041-27-2;2,3-dimethoxyfluoren-9-one;SCHEMBL7984104;DTXSID00452222

Chemical Property of 2,3-Dimethoxy-9H-fluoren-9-one

Chemical Property:

• PSA: 35.53000
• LogP: 2.91520
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 240.078644241
• Heavy Atom Count: 18
• Complexity: 328

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C3=CC=CC=C3C2=O)OC

Technology Process of 2,3-Dimethoxy-9H-fluoren-9-one

There total 43 articles about 2,3-Dimethoxy-9H-fluoren-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3',4'-dimethoxy-[1,1'-biphenyl]-2-carboxylic acid (1794-58-7) → 2,3-Dimethoxyfluoren-9-one (2041-27-2)

Guidance literature:

With trifluoroacetic anhydride; In chloroform; for 0.5h; Ambient temperature;

DOI:10.1055/s-1998-2113

Reference yield: 91.0%

C15H13ClO3 → 1,2-dimethoxy-9H-fluoren-9-one (42523-09-1) + 2,3-Dimethoxyfluoren-9-one (2041-27-2)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; at 20 ℃; for 2.5h; Overall yield = 93 %; Overall yield = 67.0 mg; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02851

Reference yield: 87.0%

carbon dioxide (124-38-9,18923-20-1) + 2-bromo-4,5-dimethoxy-1,1'-biphenyl (1260216-13-4) → 2,3-Dimethoxyfluoren-9-one (2041-27-2)

Guidance literature:

carbon dioxide; 2-bromo-4,5-dimethoxy-1,1'-biphenyl; With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;

With methanesulfonic acid; at 20 ℃;

upstream raw materials:

1,2-dimethoxybenzene

2-(toluene-4-sulfonylamino)-benzoic acid

3',4'-dimethoxy-[1,1'-biphenyl]-2-carboxylic acid

(2-bromophenyl)-(3,4-dimethoxyphenyl)methanone