Diethyl 3,5-diphenyl-1h-pyrrole-2,4-dicarboxylate

Base Information

Chemical Name:Diethyl 3,5-diphenyl-1h-pyrrole-2,4-dicarboxylate
CAS No.:3651-14-7
Molecular Formula:C22H21NO4
Molecular Weight:363.4064
Hs Code.:
NSC Number:157304
DSSTox Substance ID:DTXSID30303197
Wikidata:Q82048361

Synonyms:diethyl 3,5-diphenyl-1h-pyrrole-2,4-dicarboxylate;3651-14-7;NSC157304;DTXSID30303197;NSC-157304

Suppliers and Price of Diethyl 3,5-diphenyl-1h-pyrrole-2,4-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Diethyl 3,5-diphenyl-1h-pyrrole-2,4-dicarboxylate

Chemical Property:

Vapor Pressure:8.05E-14mmHg at 25°C
Boiling Point:588.3°C at 760 mmHg
Flash Point:309.6°C
Density:1.183g/cm³
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:363.14705815
Heavy Atom Count:27
Complexity:497

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C1C2=CC=CC=C2)C(=O)OCC)C3=CC=CC=C3

Technology Process of Diethyl 3,5-diphenyl-1h-pyrrole-2,4-dicarboxylate

There total 3 articles about Diethyl 3,5-diphenyl-1h-pyrrole-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 33831-72-0
ethyl 3-amino-3-phenylprop-2-enoate

: 3651-14-7
diethyl 3,5-diphenyl-1H-pyrrole-2,4-dicarboxylate

Guidance literature:: With oxygen; potassium acetate; copper diacetate; In dimethyl sulfoxide; at 120 ℃; for 8h; Schlenk technique;
DOI:10.1002/ejoc.201900341

Reference yield: 65.0%

: NHCC₆H₅CHC(OC₂H₅)OZnBr

: 3651-14-7
diethyl 3,5-diphenyl-1H-pyrrole-2,4-dicarboxylate

Guidance literature:: With oxygen; copper diacetate; platinum(II) 2,4-pentanedionate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 110 ℃; for 6h; Inert atmosphere; Schlenk technique;
DOI:10.1002/asia.202100860

Reference yield:

: 100-47-0
benzonitrile

: 3651-14-7
diethyl 3,5-diphenyl-1H-pyrrole-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; methanesulfonic acid / tetrahydrofuran / Reflux

2: copper diacetate; potassium acetate; oxygen / dimethyl sulfoxide / 8 h / 120 °C / Schlenk technique

With methanesulfonic acid; oxygen; potassium acetate; copper diacetate; zinc; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1002/ejoc.201900341