2-chloro-N-(4-fluoro-2,6-dimethylphenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(4-fluoro-2,6-dimethylphenyl)acetamide
• CAS No.: 443-35-6
• Molecular Formula: C₁₀H₁₁ClFNO
• Molecular Weight: 215.655
• DSSTox Substance ID: DTXSID701235459
• Mol file: 443-35-6.mol

Synonyms:2-chloro-N-(4-fluoro-2,6-dimethylphenyl)acetamide;443-35-6;DTXSID701235459

Chemical Property of 2-chloro-N-(4-fluoro-2,6-dimethylphenyl)acetamide

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 215.0513198
• Heavy Atom Count: 14
• Complexity: 200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1NC(=O)CCl)C)F

Technology Process of 2-chloro-N-(4-fluoro-2,6-dimethylphenyl)acetamide

There total 3 articles about 2-chloro-N-(4-fluoro-2,6-dimethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethylfluorobenzene (461-97-2) → chloro-acetic acid-(4-fluoro-2,6-dimethyl-anilide) (443-35-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid anhydride; acetic acid; nitric acid

2: Raney nickel; ethanol / Hydrogenation

With ethanol; nitric acid; acetic anhydride; nickel; acetic acid;

Reference yield:

2,6-dimethyl-4-fluoro-1-nitro-benzene (315-12-8) → chloro-acetic acid-(4-fluoro-2,6-dimethyl-anilide) (443-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; ethanol / Hydrogenation

With ethanol; nickel;

Reference yield:

2,6-dimethyl-4-fluoroaniline (392-70-1) + chloroacetyl chloride (79-04-9) → chloro-acetic acid-(4-fluoro-2,6-dimethyl-anilide) (443-35-6)

Guidance literature:

upstream raw materials:

2,6-dimethyl-4-fluoroaniline

chloroacetyl chloride

3,5-dimethylfluorobenzene

2,6-dimethyl-4-fluoro-1-nitro-benzene

Downstream raw materials:

2-(diethylamino)-N-(4-fluoro-2,6-dimethylphenyl)acetamide