2-(ETHYLTHIO)-6-METHYLPYRIMIDIN-4-OL

Base Information

• Chemical Name: 2-(ETHYLTHIO)-6-METHYLPYRIMIDIN-4-OL
• CAS No.: 3019-18-9
• Molecular Formula: C7H10N2OS
• Molecular Weight: 170.235
• Hs Code.: 2933599090
• Mol file: 3019-18-9.mol

Synonyms:2-(ethylsulfanyl)-6-methyl-4(3H)-pyrimidinone;S-ethyl-6-methyl-2-thiouracil;2-Aethylmercapto-6-methyl-3H-pyrimidin-4-on;2-ethylsulfanyl-6-methylpyrimidin-4(3H)-one;4-pyrimidinol,2-(ethylthio)-6-methyl;F0261-0004;2-ethylsulfanyl-6-methyl-3H-pyrimidin-4-one;

Chemical Property of 2-(ETHYLTHIO)-6-METHYLPYRIMIDIN-4-OL

Chemical Property:

• Vapor Pressure: 0.00542mmHg at 25°C
• Melting Point: 145 °C
• Boiling Point: 274.4°C at 760 mmHg
• PKA: 8.34±0.50(Predicted)
• Flash Point: 119.8°C
• PSA: 71.05000
• Density: 1.25g/cm³
• LogP: 1.19030

Purity/Quality:

98%min ^*data from raw suppliers

2-Ethylsulfanyl-6-methyl-pyrimidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(ETHYLTHIO)-6-METHYLPYRIMIDIN-4-OL

There total 11 articles about 2-(ETHYLTHIO)-6-METHYLPYRIMIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6-methyl-2-thiouracil (56-04-2,91795-77-6) + ethyl bromide (74-96-4) → 2-(ethylsulfanyl)-6-methylpyrimidin-4(3H)-one (3019-18-9)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 50 ℃; Further Variations:; Temperatures; Kinetics;

DOI:10.1134/S1070428007010125

Reference yield: 84.0%

ethyl bromide (74-96-4) + 4-hydroxy-2-mercapto-6-methylpyrimidine S-sodium salt (22874-42-6) → 2-(ethylsulfanyl)-6-methylpyrimidin-4(3H)-one (3019-18-9)

Guidance literature:

In 1,4-dioxane; water; at 50 ℃; for 0.25h; Temperature; Kinetics;

DOI:10.1007/s10593-008-0105-6

Reference yield:

→ 2-(ethylsulfanyl)-6-methylpyrimidin-4(3H)-one (3019-18-9)

Guidance literature:

at 170 ℃;

upstream raw materials:

6-methyl-2-thiouracil

ethyl iodide

ethyl acetoacetate

ethyl bromide

Downstream raw materials:

6-methyl-2-piperidinopyrimidin-4(3H)-one

2-dimethylamino-6-methyl-3H-pyrimidin-4-one

N-acetyl-sulfanilic acid-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-ylamide)

2-hydrazino-6-methylpyrimidin-4(3H)-one