1,2-Benzenedicarboxylic acid, 4-bromo-, 2-methyl ester

Base Information

• Chemical Name: 1,2-Benzenedicarboxylic acid, 4-bromo-, 2-methyl ester
• CAS No.: 208457-45-8
• Molecular Formula: C9H7BrO4
• Molecular Weight: 259.056
• Mol file: 208457-45-8.mol

Synonyms:4-bromo-1,2-benzenedicarboxylic acid 2-methyl ester;1,2-Benzenedicarboxylic acid,4-bromo-,2-methyl ester;

Chemical Property of 1,2-Benzenedicarboxylic acid, 4-bromo-, 2-methyl ester

Chemical Property:

• PSA: 66.43000
• LogP: 0.59920

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Benzenedicarboxylic acid, 4-bromo-, 2-methyl ester

There total 3 articles about 1,2-Benzenedicarboxylic acid, 4-bromo-, 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromophthalic anhydride (86-90-8) → 5-bromo-2-(methoxycarbonyl)benzoic acid (208457-46-9) + 4-bromo-2-(methoxycarbonyl)benzoic acid (208457-45-8)

Guidance literature:

4-bromophthalic anhydride; With sodium methylate; In tetrahydrofuran; methanol; for 0.166667h; Heating / reflux;

With hydrogenchloride; In water;

Reference yield:

chloro-trimethyl-silane (75-77-4) + 4-bromophthalic acid (6968-28-1) → 5-bromo-2-(methoxycarbonyl)benzoic acid (208457-46-9) + 4-bromo-2-(methoxycarbonyl)benzoic acid (208457-45-8)

Guidance literature:

In methanol; at 20 ℃; for 12h; Overall yield = 94 %; Overall yield = 13.9 g; Cooling with ice;

DOI:10.1016/j.ejmech.2017.04.046

Reference yield:

phthalic anhydride (85-44-9) → 5-bromo-2-(methoxycarbonyl)benzoic acid (208457-46-9) + 4-bromo-2-(methoxycarbonyl)benzoic acid (208457-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; sodium hydroxide / water / 72 h / Reflux

2: methanol / 12 h / 20 °C / Cooling with ice

With bromine; sodium hydroxide; In methanol; water;

DOI:10.1016/j.ejmech.2017.04.046

upstream raw materials:

4-bromophthalic anhydride

phthalic anhydride

chloro-trimethyl-silane

4-bromophthalic acid

Downstream raw materials:

benzoic acid