2-hydroxy-1-phenylpentan-1-one

Base Information

• Chemical Name: 2-hydroxy-1-phenylpentan-1-one
• CAS No.: 20907-23-7
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol file: 20907-23-7.mol

Synonyms:

Chemical Property of 2-hydroxy-1-phenylpentan-1-one

Chemical Property:

• Vapor Pressure: 0.0014mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxy-1-phenylpentan-1-one

There total 19 articles about 2-hydroxy-1-phenylpentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(((1-oxo-1-phenylpentan-2-yl)oxy)carbonyl)cyclopropane-1-carboxylic acid → 2-hydroxy-1-phenylpentan-1-one (20907-23-7)

Guidance literature:

With water; potassium hydroxide; In methanol; dichloromethane; at 20 - 25 ℃; for 0.5h;

DOI:10.1002/adsc.201900271

Reference yield: 85.0%

benzaldehyde (100-52-7) + butyraldehyde (123-72-8) → 2-hydroxy-1-phenylpentan-1-one (20907-23-7) + 1-hydroxy-1-phenylpentan-2-one (68487-09-2)

Guidance literature:

With 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; caesium carbonate; In m-xylene; at 20 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1039/c3ob42486c

Reference yield: 60.0%

phenyl butyl ketone (1009-14-9) → 2-hydroxy-1-phenylpentan-1-one (20907-23-7) + C11H14O3

Guidance literature:

phenyl butyl ketone; With lithium diisopropyl amide; In tetrahydrofuran; hexane; for 0.5h; Cooling with acetone-dry ice;

With MoO₅*pyridine*HMPA; In tetrahydrofuran; hexane; at -22 ℃;

DOI:10.15227/orgsyn.064.0127

upstream raw materials:

α-bromovalerophenone

diethyl 1-trimethylsilyloxy-2-oxo-1-phenylpentylphosphonate

1-phenyl-1,2-pentanedione

aluminium trichloride

Refernces

• 1、 Patil, Pravin C.,Luzzio, Frederick A.,Demuth, Donald R.. "Oxazoles for click chemistry II: Synthesis of extended heterocyclic scaffolds". supporting information. p. 3039 - 3041. Retrieved 2015/05/27.
• 2、 Jin, Ming Yu,Kim, Sun Min,Mao, Hui,Ryu, Do Hyun,Song, Choong Eui,Yang, Jung Woon. "Chemoselective and repetitive intermolecular cross-acyloin condensation reactions between a variety of aromatic and aliphatic aldehydes using a robust N-heterocyclic carbene catalyst". supporting information. p. 1547 - 1550. Retrieved 2014/03/21.