Benzoic acid, 4-(1H-imidazol-2-yl)-, ethyl ester

Base Information

• Chemical Name: Benzoic acid, 4-(1H-imidazol-2-yl)-, ethyl ester
• CAS No.: 210962-26-8
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.23600
• Mol file: 210962-26-8.mol

Synonyms:Benzoic acid, 4-(1H-imidazol-2-yl)-, ethyl ester;ethyl 4-(2-1H-imidazolyl)benzoate;

Chemical Property of Benzoic acid, 4-(1H-imidazol-2-yl)-, ethyl ester

Chemical Property:

• PSA: 54.98000
• LogP: 2.25340

Purity/Quality:

99% ^*data from raw suppliers

4-(1H-IMIDAZOL-2-YL)-BENZOIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-(1H-imidazol-2-yl)-, ethyl ester

There total 2 articles about Benzoic acid, 4-(1H-imidazol-2-yl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

ethyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate (100134-80-3) → ethyl 4-(1H-imidazol-2-yl)benzoate (210962-26-8)

Guidance literature:

With barium permanganate;

DOI:10.1016/S0968-0896(03)00436-X

Reference yield:

ethyl 4-cyanobenzoate (7153-22-2) → ethyl 4-(1H-imidazol-2-yl)benzoate (210962-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / BaMnO₄

With barium permanganate;

DOI:10.1016/S0968-0896(03)00436-X

Reference yield: 42.0%

carbonic acid dimethyl ester (616-38-6) + ethyl 4-(1H-imidazol-2-yl)benzoate (210962-26-8) → methyl 4-(1-methyl-1H-imidazol-2-yl)benzoate (175152-65-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; at 100 ℃; for 44h;

DOI:10.1016/S0968-0896(03)00436-X

upstream raw materials:

ethyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate

ethyl 4-cyanobenzoate

Downstream raw materials:

methyl 4-(1-methyl-1H-imidazol-2-yl)benzoate

4-(2-1H-imidazolyl)benzoic acid hydrochloride