175152-65-5Relevant articles and documents
Polymer support assisted selective functionalization of Azoles using a palladium-catalyzed coupling reaction
Kondo, Yoshinori,Komine, Takashi,Sakamoto, Takao
, p. 3111 - 3113 (2000)
(matrix presented) Regioselective palladium-catalyzed monoarylation of azoles was achieved using iodobenzoate immobilized on an insoluble polymer support. The positional selectivity for the coupling reaction was dramatically influenced by the presence of Cul. No diarylation was observed in either case. Unsymmetrical diarylation was also obtained with the polymer support using sequential coupling reactions.
Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase
Mano, Takashi,Stevens, Rodney W.,Ando, Kazuo,Nakao, Kazunari,Okumura, Yoshiyuki,Sakakibara, Minoru,Okumura, Takako,Tamura, Tetsuya,Miyamoto, Kimitaka
, p. 3879 - 3887 (2007/10/03)
Replacement of the dihydroquinolinone pharmacophore of Zeneca's ZD2138 by ionizable imidazolylphenyl moiety has lead to the discovery of a novel series of potent and orally active 5-lipoxygenase (5-LO) inhibitors. The synthesis and structure-activity relationship (SAR) of this series of compounds are described herein.
