Benzamide, N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-((4-iodo-2-methylphenyl)amino)-

Base Information

Chemical Name:Benzamide, N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-((4-iodo-2-methylphenyl)amino)-
CAS No.:212631-61-3
Molecular Formula:C18H16F3IN2O2
Molecular Weight:476.23200
Hs Code.:
UNII:WQ5121ZGT3
DSSTox Substance ID:DTXSID70433306
Wikidata:Q27165235
ChEMBL ID:CHEMBL1474985
Mol file:212631-61-3.mol

Synonyms:PD 198306;PD198306

Suppliers and Price of Benzamide, N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-((4-iodo-2-methylphenyl)amino)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PD 198306
10mg
$ 573.00

TRC
PD198306
10mg
$ 245.00

Tocris
PD198306 ≥98%(HPLC)
10
$ 320.00

Sigma-Aldrich
MEK Inhibitor VIII - CAS 212631-61-3 - Calbiochem
5mg
$ 260.00

Medical Isotopes, Inc.
PD198306
5 mg
$ 650.00

Cayman Chemical
PD 198306 ≥98%
5mg
$ 205.00

Cayman Chemical
PD 198306 ≥98%
10mg
$ 321.00

Cayman Chemical
PD 198306 ≥98%
1mg
$ 59.00

ApexBio Technology
PD198306
10mg
$ 465.00

American Custom Chemicals Corporation
MEK1/2 INHIBITOR II 95.00%
10MG
$ 782.23

Total 6 raw suppliers

Chemical Property of Benzamide, N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-((4-iodo-2-methylphenyl)amino)-

Chemical Property:

Melting Point:125-127 °C
PKA:-3.95±0.50(Predicted)
PSA：50.36000
Density:1.686g/cm3
LogP:5.29580
Storage Temp.:Store at +4°C
Solubility.:Soluble in DMSO
XLogP3:5.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:476.02086
Heavy Atom Count:26
Complexity:497

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

PD 198306 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)I)NC2=C(C(=C(C=C2C(=O)NOCC3CC3)F)F)F
Description PD 198306 is an orally bioavailable and potent inhibitor of MAPK kinase 1/2 (MEK1/2; IC50 = 8 nM). It is selective for MEK1/2 over ERK, c-Src, PI3Kγ, and cyclin-dependent kinases (IC50s = >1 μM). PD 198306 (3-100 μM) reduces ERK1/2 phosphorylation and inhibits growth of HL-60 cells in vitro. In vivo, PD 198306 (10-30 mg/kg) reduces ERK1/2 phosphorylation and matrix metalloproteinase-1 (MMP-1) expression in a dose-dependent manner in a rabbit model of osteoarthritis. It also reduces ERK1/2 activity in the lumbar spinal cord and blocks static allodynia in rat models of neuropathic pain induced by streptozotocin or chronic constriction injury.
Uses PD 198306 is a cell-permeable and highly selective potent inhibitor of MEK 1/2.

Technology Process of Benzamide, N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-((4-iodo-2-methylphenyl)amino)-

There total 3 articles about Benzamide, N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-((4-iodo-2-methylphenyl)amino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 3,4,5-Trifluoro-2-(4-iodo-2-methyl-phenylamino)-benzoic acid

: O-(cyclopropylmethyl)hydroxylamine hydrochloride

: 212631-61-3
N-cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methyl-phenylamino)-benzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2008.10.054