Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, (1S)-1-benzoyl-2-methylpropyl ester

Base Information

Chemical Name:Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, (1S)-1-benzoyl-2-methylpropyl ester
CAS No.:212896-13-4
Molecular Formula:C18H25NO5
Molecular Weight:335.4
Hs Code.:

Synonyms:

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Chemical Property of Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, (1S)-1-benzoyl-2-methylpropyl ester

Chemical Property:

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Technology Process of Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, (1S)-1-benzoyl-2-methylpropyl ester

There total 4 articles about Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, (1S)-1-benzoyl-2-methylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 4530-20-5
BOC-glycine

: 97551-20-7
S-(+)-1-phenyl-2-hydroxy-3-methylbutanone

: 212896-13-4
(1S)-1-benzoyl-2-(tert-butoxycarbonylamino)-2-methylpropyl ethanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/acs.joc.9b02659

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 212896-13-4
(1S)-1-benzoyl-2-(tert-butoxycarbonylamino)-2-methylpropyl ethanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / DCC; BtOH; iPr₂NEt / tetrahydrofuran / -20 - 20 °C

2: 70 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C

3: 80 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

With dmap; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Substitution / 2: Grignard reaction / 3: Esterification;
DOI:10.1021/jo991736l

Reference yield:

: 111199-07-6
(S)-2-hydroxy-3,N,N-trimethylbutanamide

: 212896-13-4
(1S)-1-benzoyl-2-(tert-butoxycarbonylamino)-2-methylpropyl ethanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C

2: 80 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Grignard reaction / 2: Esterification;
DOI:10.1021/jo991736l