4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE

Base Information

• Chemical Name: 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
• CAS No.: 216163-53-0
• Molecular Formula: C17H15BrN4O
• Molecular Weight: 371.236
• Mol file: 216163-53-0.mol

Synonyms:

Chemical Property of 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE

Chemical Property:

• PSA: 66.91000
• LogP: 4.63040
• Storage Temp.: -20°C

Purity/Quality:

≥98% ^*data from raw suppliers

PD174265 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity.
• Uses: PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity.

Technology Process of 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE

There total 1 articles about 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

propionyl chloride (79-03-8) + 6-amino-4-[(3-bromophenyl)amino]quinazoline (169205-78-1) → N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]propanamide (216163-53-0)

Guidance literature:

In tetrahydrofuran; at 25 ℃;

Reference yield: 9.0%

N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]propanamide (216163-53-0) + (E)-4-(dimethylamino)-2-butenoic acid hydrochloride (1130155-48-4) → 4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide (220699-51-4)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2008.02.053

upstream raw materials:

propionyl chloride

6-amino-4-[(3-bromophenyl)amino]quinazoline

Downstream raw materials:

4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide