Technology Process of Cyclohexanamine, 2-propyl-, cis-
There total 5 articles about Cyclohexanamine, 2-propyl-, cis- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(n-propyl)cyclohexanone;
With
(R)-1-phenyl-ethyl-amine; toluene-4-sulfonic acid;
In
toluene;
for 24h;
Heating;
With
hydrogen; nickel;
In
ethanol;
at 20 ℃;
for 96h;
under 3000.24 Torr;
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
at 45 ℃;
under 3000.24 Torr;
DOI:10.1021/jm060133g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 52 percent / H2 / Pd/C / ethanol / 16 h / 20 °C / 1551.44 Torr
2.1: (R)-(+)-1-phenyl-ethylamine; p-TsOH / toluene / 24 h / Heating
2.2: Raney Ni; H2 / ethanol / 96 h / 20 °C / 3000.24 Torr
2.3: H2 / Pd/C / ethanol / 45 °C / 3000.24 Torr
With
(R)-1-phenyl-ethyl-amine; hydrogen; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
ethanol; toluene;
DOI:10.1021/jm060133g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropylamide / tetrahydrofuran / 0.75 h / -78 °C
1.2: 23 percent / tetrahydrofuran / 16 h / -78 - 20 °C
2.1: 52 percent / H2 / Pd/C / ethanol / 16 h / 20 °C / 1551.44 Torr
3.1: (R)-(+)-1-phenyl-ethylamine; p-TsOH / toluene / 24 h / Heating
3.2: Raney Ni; H2 / ethanol / 96 h / 20 °C / 3000.24 Torr
3.3: H2 / Pd/C / ethanol / 45 °C / 3000.24 Torr
With
(R)-1-phenyl-ethyl-amine; hydrogen; toluene-4-sulfonic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jm060133g
