methyl 3-amino-5-chlorobenzoate

Base Information

• Chemical Name: methyl 3-amino-5-chlorobenzoate
• CAS No.: 21961-31-9
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Hs Code.: 2922499990
• Mol file: 21961-31-9.mol

Synonyms:5-carbomethoxy-3-chloro aniline;3-amino-5-chloro-benzoic acid methyl ester;Methyl 3-amino-5-chlorobenzoate;methyl 5-chloro-3-aminobenzoate;

Chemical Property of methyl 3-amino-5-chlorobenzoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 329.413oC at 760 mmHg
• Flash Point: 153.024oC
• PSA: 52.32000
• Density: 1.311g/cm3
• LogP: 2.29000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-Amino-5-chlorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-amino-5-chlorobenzoate

There total 3 articles about methyl 3-amino-5-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-amino-5-chloro-benzoic acid (21961-30-8) → methyl 3-amino-5-chlorobenzoate (21961-31-9)

Guidance literature:

With thionyl chloride; at 0 ℃; for 12h; Reflux;

Reference yield: 88.0%

3-chloro-5-nitro-benzoic acid methyl ester (36138-28-0) → methyl 3-amino-5-chlorobenzoate (21961-31-9)

Guidance literature:

With tin(ll) chloride; In 1,4-dioxane; at 70 ℃; for 2h;

Reference yield:

3-chloro-5-nitrobenzoic acid (34662-36-7) → methyl 3-amino-5-chlorobenzoate (21961-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 12 h / 70 °C

2: iron; ammonium chloride / water; ethanol / 12 h / 80 °C

With thionyl chloride; iron; ammonium chloride; In ethanol; water;

upstream raw materials:

3-chloro-5-nitro-benzoic acid methyl ester

methanol

3-amino-5-chloro-benzoic acid

3-chloro-5-nitrobenzoic acid

Downstream raw materials:

3-chloro-5-methanesulfonylamino-benzoic acid methyl ester

3-chloro-5-isobutyrylamino-benzoic acid methyl ester

3-chloro-5-(4-chloro-butyrylamino)-benzoic acid methyl ester

3-chloro-5-isopropylamino-benzoic acid methyl ester

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