(4-Aminophenyl)(4-nitrophenyl)methanone

Base Information

• Chemical Name: (4-Aminophenyl)(4-nitrophenyl)methanone
• CAS No.: 22020-57-1
• Molecular Formula: C13H10N2O3
• Molecular Weight: 242.234
• DSSTox Substance ID: DTXSID10600090
• Nikkaji Number: J83.130A
• Wikidata: Q82496050
• Mol file: 22020-57-1.mol

Synonyms:22020-57-1;(4-Aminophenyl)(4-nitrophenyl)methanone;SCHEMBL9189648;DTXSID10600090

Chemical Property of (4-Aminophenyl)(4-nitrophenyl)methanone

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 242.06914219
• Heavy Atom Count: 18
• Complexity: 311

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)C2=CC=C(C=C2)[N+](=O)[O-])N

Technology Process of (4-Aminophenyl)(4-nitrophenyl)methanone

There total 9 articles about (4-Aminophenyl)(4-nitrophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-nitrobenzyl chloride (619-73-8) + aniline (62-53-3) → 4-amino-4'-nitro-benzophenone (22020-57-1)

Guidance literature:

With 3C₁₈H₂₆NO₃⁽¹⁺⁾*HPMo₁₁VO₄₀^(3-); oxygen; In chloroform; dimethyl sulfoxide; at 150 ℃; for 8h; Green chemistry;

DOI:10.1039/c8cy01423j

Reference yield:

acetic acid-[4-(4-nitro-benzoyl)-anilide] (22020-58-2) → 4-amino-4'-nitro-benzophenone (22020-57-1)

Guidance literature:

Reference yield:

Acetanilid (103-84-4) → 4-amino-4'-nitro-benzophenone (22020-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / nitrobenzene / 100 °C

2: conc. aq. HCl / ethanol / Heating

With hydrogenchloride; aluminium trichloride; In ethanol; nitrobenzene;

DOI:10.1016/S0960-894X(97)10192-5

upstream raw materials:

N-<4-(4-Nitro-benzoyl)-phenyl>-phthalimid

bis(4-nitrophenyl)methane

acetic acid-[4-(4-nitro-benzoyl)-anilide]

ethanol

Downstream raw materials:

4,4'-diaminobenzophenone

[4-(4-Nitro-benzoyl)-phenyl]-urea

acetic acid-[4-(4-nitro-benzoyl)-anilide]

Refernces

• 1、 Ogino, Takashi,Tsuji, Kiyoshi,Tojo, Takashi,Igari, Norihiro,Seki, Nobuo,Sudo, Yu,Manda, Toshitaka,Nishigaki, Fusako,Matsuo, Masaaki. "Discovery of FR115092 : A novel antinephritic agent". . p. 75 - 80. Retrieved 2007/10/03.