Methyl 1-phenyl-1H-benzo[d]iMidazole-5-carboxylate

Base Information

• Chemical Name: Methyl 1-phenyl-1H-benzo[d]iMidazole-5-carboxylate
• CAS No.: 220495-70-5
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.26800
• Hs Code.: 2933990090
• Mol file: 220495-70-5.mol

Synonyms:Methyl 1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;methyl 1-phenylbenzimidazole-5-carboxylate;

Chemical Property of Methyl 1-phenyl-1H-benzo[d]iMidazole-5-carboxylate

Chemical Property:

• PSA: 44.12000
• LogP: 2.81210

Purity/Quality:

99% ^*data from raw suppliers

Methyl1-phenyl-1H-benzo[d]imidazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-phenyl-1H-benzo[d]iMidazole-5-carboxylate

There total 8 articles about Methyl 1-phenyl-1H-benzo[d]iMidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl(2,4,6-trimethoxyphenyl)iodonium(III) triflate + methyl 1H-benzo[d]imidazole-5-carboxylate (26663-77-4) → 1-phenylbenzimidazole-6-carboxylic acid methyl ester + 1-phenylbenzimidazole-5-carboxylic acid methyl ester (220495-70-5)

Guidance literature:

With copper (I) acetate; triethylamine; In dichloromethane; at 50 ℃; for 6h; Overall yield = 84 %; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.04.012

Reference yield:

2-nitrodiphenylamine-4-carboxylic acid (16927-49-4) → 1-phenylbenzimidazole-5-carboxylic acid methyl ester (220495-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl(g) / 18 h / Heating

2: H₂ / 5 percent Pd/C / methanol; ethyl acetate

3: 2-methoxy-ethanol / 3 h / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; 2-methoxy-ethanol; ethyl acetate;

DOI:10.1021/jm9804681

Reference yield:

3-nitro-4-phenylaminobenzoic acid methyl ester (148304-23-8) → 1-phenylbenzimidazole-5-carboxylic acid methyl ester (220495-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / methanol; ethyl acetate

2: 2-methoxy-ethanol / 3 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; 2-methoxy-ethanol; ethyl acetate;

DOI:10.1021/jm9804681

upstream raw materials:

3-amino-4-phenylaminobenzoic acid methyl ester

formamidine acetic acid

2-nitrodiphenylamine-4-carboxylic acid

3-nitro-4-phenylaminobenzoic acid methyl ester