tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Base Information

Chemical Name:tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate
CAS No.:220862-18-0
Molecular Formula:C23H27NO3
Molecular Weight:365.472
Hs Code.:2933990090
DSSTox Substance ID:DTXSID60475871
Wikidata:Q82306688
Mol file:220862-18-0.mol

Synonyms:tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate;220862-18-0;tert-butyl 2-(1-benzyl-2-ethylindol-4-yl)oxyacetate;tert-butyl 2-[(1-benzyl-2-ethyl-1H-indol-4-yl)oxy]acetate;C23H27NO3;tert-Butyl 2-((1-benzyl-2-ethyl-1H-indol-4-yl)oxy)acetate;SCHEMBL5697008;DTXSID60475871;BKKATOCEHZVOTC-UHFFFAOYSA-N;AKOS015842871;FT-0659199;A815909;[[2-Ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid tert-butyl ester

Suppliers and Price of tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate 95+%
1g
$ 947.00

Chemenu
tert-butyl2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate 95%
1g
$ 893.00

American Custom Chemicals Corporation
TERT-BUTYL 2-(1-BENZYL-2-ETHYL-1H-INDOL-4-YLOXY)ACETATE 95.00%
5G
$ 909.56

Alichem
tert-Butyl2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate
1g
$ 791.04

Total 16 raw suppliers

Chemical Property of tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
PSA：40.46000
LogP:4.97250
XLogP3:5.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:365.19909372
Heavy Atom Count:27
Complexity:481

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=CC2=C(N1CC3=CC=CC=C3)C=CC=C2OCC(=O)OC(C)(C)C

Technology Process of tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

There total 15 articles about tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 172733-06-1
1-benzyl-2-ethyl-1H-indol-4-ol

: 220862-18-0
tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Guidance literature:: 1-benzyl-2-ethyl-1H-indol-4-ol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

bromoacetic acid tert-butyl ester; In N,N-dimethyl-formamide; for 0.5h;
DOI:10.1021/jm060136t

Reference yield:

: 39843-70-4
4-(benzyloxy)-2-ethyl-1H-indole

: 220862-18-0
tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.08 h / 0 °C

1.2: 83 percent / dimethylformamide / 2 h

2.1: 68 percent / H₂ / Pd/C / methanol / 2 h / 2068.59 Torr

3.1: NaH / dimethylformamide / 0.08 h / 20 °C

3.2: 87 percent / dimethylformamide / 0.5 h

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm060136t

Reference yield:

: 889675-06-3
1-(4-(benzyloxy)-1H-indol-2-yl)ethanol

: 220862-18-0
tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 77 percent / NaBH₄; trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

2.1: NaH / dimethylformamide / 0.08 h / 0 °C

2.2: 83 percent / dimethylformamide / 2 h

3.1: 68 percent / H₂ / Pd/C / methanol / 2 h / 2068.59 Torr

4.1: NaH / dimethylformamide / 0.08 h / 20 °C

4.2: 87 percent / dimethylformamide / 0.5 h

With sodium tetrahydroborate; hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060136t