Chemical Property of Varespladib
Chemical Property:
- Vapor Pressure:9.53E-19mmHg at 25°C
- Melting Point:230-234 °C
- Boiling Point:667.9°C at 760 mmHg
- PKA:3.12±0.40(Predicted)
- Flash Point:357.7°C
- PSA：111.62000
- Density:1.32±0.1 g/cm3(Predicted)
- LogP:3.08370
- Storage Temp.:-20°C
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- XLogP3:2.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:8
- Exact Mass:380.13722174
- Heavy Atom Count:28
- Complexity:589
- Purity/Quality:
-
99%, *data from raw suppliers
LY 315920 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
Useful:
- Canonical SMILES:CCC1=C(C2=C(N1CC3=CC=CC=C3)C=CC=C2OCC(=O)O)C(=O)C(=O)N
- Recent ClinicalTrials:A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by BCMA CAR-T Therapy in Transplant-Ineligible Patients With New-diagnosed Multiple Myeloma
- Recent EU Clinical Trials:PONV – Histamin - Vitamin C
-
Uses
VARESPLADIB is used as a PLA2 inhibitor (Phospholipase A2 Enzyme inhibitor). Varespladib has been used as a secretory phospholipase A (sPLA2) inhibitor: to test its effect on the human astrocytes subjected to psychosine-induced toxicityto test its neutralization functionality on the black snake species P. colletti?venom in combination with snake venom metalloproteinases (SVMP)-inhibitor, marimastat to test its protective functionality on envenoming by vipers
