tert-butyl 2-{[1-benzyl-3-(carbaMoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetate

Base Information

Chemical Name:tert-butyl 2-{[1-benzyl-3-(carbaMoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetate
CAS No.:889675-08-5
Molecular Formula:C25H28N2O5
Molecular Weight:436.51231
Hs Code.:
Mol file:889675-08-5.mol

Synonyms:-1-benzyl-2-ethyl-1H-indol-4-yl);tert-Butyl 2-((3-(2-amino-2-oxoacetyl);tert-butyl 2-(3-(2-aMino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate;tert-butyl 2-{[1-benzyl-3-(carbaMoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetate;2-[[2-ethyl-3-oxamoyl-1-(phenylmethyl)-4-indolyl]oxy]acetic acid tert-butyl ester;Acetic acid, 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-, 1,1-dimethylethyl ester

Suppliers and Price of tert-butyl 2-{[1-benzyl-3-(carbaMoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl2-((3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yl)oxy)acetate 95+%
1g
$ 668.00

Chemenu
tert-butyl2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate 95%
1g
$ 632.00

American Custom Chemicals Corporation
TERT-BUTYL 2-(3-(2-AMINO-2-OXOACETYL)-1-BENZYL-2-ETHYL-1H-INDOL-4-YLOXY)ACETATE 95.00%
5G
$ 909.56

Total 18 raw suppliers

Chemical Property of tert-butyl 2-{[1-benzyl-3-(carbaMoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:176-178 °C
Boiling Point:635.281°C at 760 mmHg
PKA:12?+-.0.50(Predicted)
Flash Point:338.006°C
Density:1.201g/cm³

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2-((3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yl)oxy)acetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 2-{[1-benzyl-3-(carbaMoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetate

There total 19 articles about tert-butyl 2-{[1-benzyl-3-(carbaMoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 220862-18-0
tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

: 79-37-8
oxalyl dichloride

: 889675-08-5
tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Guidance literature:: tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate; oxalyl dichloride; In dichloromethane; at 20 ℃; for 2h;

With 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; at 20 ℃; Further stages.;
DOI:10.1021/jo070643y

Reference yield:

: (1-benzyl-3-chlorooxalyl-2-ethyl-1H-indol-4-yloxy)-acetic acid tert-butyl ester

: 889675-08-5
tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Guidance literature:: With ammonia; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1021/jm060136t

Reference yield:

: 39843-70-4
4-(benzyloxy)-2-ethyl-1H-indole

: 889675-08-5
tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.08 h / 0 °C

1.2: 83 percent / dimethylformamide / 2 h

2.1: 68 percent / H₂ / Pd/C / methanol / 2 h / 2068.59 Torr

3.1: NaH / dimethylformamide / 0.08 h / 20 °C

3.2: 87 percent / dimethylformamide / 0.5 h

4.1: CH₂Cl₂ / 2 h / 20 °C

5.1: 0.505 g / NH₃ / CH₂Cl₂ / 0.17 h / 20 °C

With ammonia; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060136t