4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

Base Information

Chemical Name:4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole
CAS No.:22091-40-3
Molecular Formula:C11H7ClF3NO
Molecular Weight:261.631
Hs Code.:
DSSTox Substance ID:DTXSID001214377
Mol file:22091-40-3.mol

Synonyms:4-(chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole;22091-40-3;SCHEMBL6476484;DTXSID001214377;AKOS005795006;EN300-114888;2-(4-trifluoromethyl-phenyl)-4-Chloromethyloxazole;4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]oxazole

Suppliers and Price of 4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:261.0168260
Heavy Atom Count:17
Complexity:254

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC(=CO2)CCl)C(F)(F)F

Technology Process of 4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

There total 5 articles about 4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1891-90-3
p-trifluoromethylbenzamide

: 534-07-6
1,3-Dichloroacetone

: 22091-40-3
4-(chloromethyl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: In neat (no solvent); at 130 ℃; for 4h;
DOI:10.1515/hc-2020-0117

Reference yield:

: 753479-59-3
{2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methan-1-ol

: 22091-40-3
4-(chloromethyl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: With thionyl chloride; In dichloromethane; for 2h; Reflux;
DOI:10.1016/j.bmcl.2015.09.072

Reference yield:

: 1891-90-3
p-trifluoromethylbenzamide

: 22091-40-3
4-(chloromethyl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: NaHCO₃ / 1,2-dichloro-ethane

2: SOCl₂

With thionyl chloride; sodium hydrogencarbonate; In 1,2-dichloro-ethane; 1: Alkylation / 2: Cyclization;
DOI:10.1021/jm990476x