H-D-VAL-OET HCL

Base Information

• Chemical Name: H-D-VAL-OET HCL
• CAS No.: 73913-64-1
• Molecular Formula: C₇H₁₅NO₂*ClH
• Molecular Weight: 181.663
• Hs Code.: 2922499990
• Mol file: 73913-64-1.mol

Synonyms:D-Valine,ethyl ester, hydrochloride (9CI);Ethyl D-valinate hydrochloride;

Chemical Property of H-D-VAL-OET HCL

Chemical Property:

• Appearance/Colour: White crystalline powde
• Melting Point: 120oC
• Boiling Point: 212.5 °C at 760 mmHg
• Flash Point: 82.3 °C
• PSA: 52.32000
• LogP: 2.03510
• Storage Temp.: Store at 0°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-Valine ethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-VAL-OET HCL

There total 1 articles about H-D-VAL-OET HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

ethanol (64-17-5) + D,L-valine (516-06-3,25609-85-2,7004-03-7,921-10-8) → valine ethyl ester hydrochloride (17609-47-1,23358-42-1,73913-64-1)

Guidance literature:

With chloro-trimethyl-silane; Heating;

DOI:10.1134/S1070363207040135

Reference yield: 95.0%

3-phenyloxetane-3-carboxylic acid (114012-42-9) + valine ethyl ester hydrochloride (17609-47-1,23358-42-1,73913-64-1) → ethyl (3-phenyloxetane-3-carbonyl)valinate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 0 - 25 ℃; for 24h;

DOI:10.1021/acs.orglett.0c01214

Reference yield: 92.5%

2-nitro-4-chloromethylsulfonylchlorobenzene (7592-97-4) + valine ethyl ester hydrochloride (17609-47-1,23358-42-1,73913-64-1) → 2-(4-Chloromethanesulfonyl-2-nitro-phenylamino)-3-methyl-butyric acid ethyl ester

Guidance literature:

With triethylamine; In chloroform; at 60 ℃;

upstream raw materials:

ethanol

D,L-valine

Downstream raw materials:

N-carbonyl-valine ethyl ester

4-isopropyl-1,3-dihydro-imidazol-2-one

N-(N-benzyloxycarbonyl-valyl)-valine ethyl ester

Z-Gly-Val-OH

Refernces

• 1、 Lebedev,Lebedeva,Sheludyakov,Shatunov,Ovcharuk. "Organosilicon synthesis of isocyanates: IV. Synthesis of isocyanates from aliphatic and alkylaromatic amino acid esters". . p. 581 - 585. Retrieved 2008/02/11.