CDK2 INHIBITOR II

Base Information

Chemical Name:CDK2 INHIBITOR II
CAS No.:222035-13-4
Molecular Formula:C14H11BrN4O3S
Molecular Weight:395.23100
Hs Code.:
Mol file:222035-13-4.mol

Synonyms:

Suppliers and Price of CDK2 INHIBITOR II

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CDK2inhibitorII
10mg
$ 120.00

Cayman Chemical
Cdk2 Inhibitor II ≥95%
1mg
$ 45.00

Cayman Chemical
Cdk2 Inhibitor II ≥95%
500μg
$ 25.00

Cayman Chemical
Cdk2 Inhibitor II ≥95%
5mg
$ 135.00

AK Scientific
Cdk2InhibitorII
5mg
$ 282.00

Total 15 raw suppliers

Chemical Property of CDK2 INHIBITOR II

Chemical Property:

Melting Point:>272°C (dec.)
PSA：122.03000
LogP:3.85690
Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98% ^*data from raw suppliers

CDK2inhibitorII ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM). It is cell permeable, reversible, and ATP-competitive.
Uses CDK2 inhibitor II, is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2.

Technology Process of CDK2 INHIBITOR II

There total 3 articles about CDK2 INHIBITOR II which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 222035-13-4
4-[2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]benzenesulfonamide

Guidance literature:: In ethanol; for 2h; Heating;
DOI:10.1021/jm010117d

Reference yield:

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 4392-54-5
4-aminosulfonylphenylhydrazine

: 222035-13-4
4-[2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]benzenesulfonamide

Guidance literature:: With acetic acid; for 6h; Reflux;
DOI:10.1016/j.ejmech.2019.111768

Reference yield:

: 63-74-1
sulfanilamide

: 222035-13-4
4-[2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 1 h / Cooling with ice

1.2: 3 h

2.1: acetic acid / 6 h / Reflux

With hydrogenchloride; acetic acid; sodium nitrite; In water;
DOI:10.1016/j.ejmech.2019.111768