Acetamide, N-[(1R,2S,4S,5R)-5-(benzoyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl ]-1-ethenyl-4-hydroxy-4-methylcyclohexyl]-2,2,2-trichloro-

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Chemical Name:Acetamide, N-[(1R,2S,4S,5R)-5-(benzoyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl ]-1-ethenyl-4-hydroxy-4-methylcyclohexyl]-2,2,2-trichloro-
CAS No.:222983-16-6
Molecular Formula:C23H28Cl3NO6
Molecular Weight:520.837
Hs Code.:
Mol file:222983-16-6.mol

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Chemical Property of Acetamide, N-[(1R,2S,4S,5R)-5-(benzoyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl ]-1-ethenyl-4-hydroxy-4-methylcyclohexyl]-2,2,2-trichloro-

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Technology Process of Acetamide, N-[(1R,2S,4S,5R)-5-(benzoyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl ]-1-ethenyl-4-hydroxy-4-methylcyclohexyl]-2,2,2-trichloro-

There total 2 articles about Acetamide, N-[(1R,2S,4S,5R)-5-(benzoyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl ]-1-ethenyl-4-hydroxy-4-methylcyclohexyl]-2,2,2-trichloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 98-88-4
benzoyl chloride

: 222983-15-5
2,2,2-Trichloro-N-[(1R,2S,4S,5R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,5-dihydroxy-4-methyl-1-vinyl-cyclohexyl]-acetamide

: 222983-16-6
Benzoic acid (1R,2S,4S,5R)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-5-(2,2,2-trichloro-acetylamino)-5-vinyl-cyclohexyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(99)00140-4

Reference yield:

: 162089-64-7
(1S,6S,1'S)-trichloro-N-[1-vinyl-4-methyl-6-(3',3'-dimethyl-2',4'-dioxolanyl)-cyclohex-3-enyl]acetamide

: 222983-16-6
Benzoic acid (1R,2S,4S,5R)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-5-(2,2,2-trichloro-acetylamino)-5-vinyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / OsO₄, NMO / acetone; H₂O / 4 h / Ambient temperature

2: 91 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; osmium(VIII) oxide; N-methyl-2-indolinone; triethylamine; In dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(99)00140-4