(5-(Thiophen-3-yl)pyridin-3-yl)methanol

Base Information

• Chemical Name: (5-(Thiophen-3-yl)pyridin-3-yl)methanol
• CAS No.: 223563-61-9
• Molecular Formula: C10H9NOS
• Molecular Weight: 191.25000
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00452106
• Wikidata: Q82272495
• Mol file: 223563-61-9.mol

Synonyms:(5-(thiophen-3-yl)pyridin-3-yl)methanol;223563-61-9;(5-thiophen-3-ylpyridin-3-yl)methanol;[5-(thiophen-3-yl)pyridin-3-yl]methanol;SCHEMBL7424044;DTXSID00452106;GNHNVVISNPPJFB-UHFFFAOYSA-N;5-(3-thienyl)-3-pyridylmethanol;AKOS016014455;BS-49930;CS-0197039;E78504;EN300-223726;J-501519;Z1258977089

Chemical Property of (5-(Thiophen-3-yl)pyridin-3-yl)methanol

Chemical Property:

• PSA: 61.36000
• LogP: 2.30240
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.04048508
• Heavy Atom Count: 13
• Complexity: 165

Purity/Quality:

≥95% ^*data from raw suppliers

(5-(Thiophen-3-yl)pyridin-3-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC=C1C2=CN=CC(=C2)CO

Technology Process of (5-(Thiophen-3-yl)pyridin-3-yl)methanol

There total 2 articles about (5-(Thiophen-3-yl)pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

Thien-3-ylboronic acid (6165-69-1) + (5-bromopyridin-3-yl)methanol (37669-64-0) → 3-(hydroxymethyl)-5-(3-thiophene)pyridine (223563-61-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene; at 70 ℃; for 20h;

DOI:10.1021/jm010246u

Reference yield:

5-bromo-3-pyridinecarboxylic acid (20826-04-4) → 3-(hydroxymethyl)-5-(3-thiophene)pyridine (223563-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent / BH₃*THF / tetrahydrofuran / 4 h / Heating

2: 61 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol / 20 h / 70 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium carbonate; In tetrahydrofuran; methanol; toluene; 2: Suzuki coupling reaction;

DOI:10.1021/jm010246u

Reference yield: 52.0%

3-(hydroxymethyl)-5-(3-thiophene)pyridine (223563-61-9) → 3-formyl-5-(3-thiophene)pyridine (342601-30-3)

Guidance literature:

With sodium acetate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm010246u

upstream raw materials:

Thien-3-ylboronic acid

(5-bromopyridin-3-yl)methanol

5-bromo-3-pyridinecarboxylic acid

Downstream raw materials:

3-formyl-5-(3-thiophene)pyridine