5-(Thiophen-3-yl)nicotinaldehyde

Base Information

Chemical Name:5-(Thiophen-3-yl)nicotinaldehyde
CAS No.:342601-30-3
Molecular Formula:C10H7NOS
Molecular Weight:189.23400
Hs Code.:2934999090
DSSTox Substance ID:DTXSID40452988
Wikidata:Q82273934
Mol file:342601-30-3.mol

Synonyms:5-(Thiophen-3-yl)nicotinaldehyde;342601-30-3;5-thiophen-3-ylpyridine-3-carbaldehyde;5-(thiophen-3-yl)pyridine-3-carbaldehyde;SCHEMBL13556468;DTXSID40452988;AKOS016844757;SB54764;EN300-221488;F2167-2415

Suppliers and Price of 5-(Thiophen-3-yl)nicotinaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-(Thiophen-3-yl)nicotinaldehyde 95+%
1g
$ 614.00

Chemenu
5-(thiophen-3-yl)nicotinaldehyde 95%
1g
$ 580.00

American Custom Chemicals Corporation
5-(THIOPHEN-3-YL)NICOTINALDEHYDE 95.00%
5MG
$ 505.12

Total 8 raw suppliers

Chemical Property of 5-(Thiophen-3-yl)nicotinaldehyde

Chemical Property:

PSA：58.20000
LogP:2.62260
Storage Temp.:2-8°C
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:189.02483502
Heavy Atom Count:13
Complexity:186

Purity/Quality:

97% ^*data from raw suppliers

5-(Thiophen-3-yl)nicotinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC=C1C2=CN=CC(=C2)C=O

Technology Process of 5-(Thiophen-3-yl)nicotinaldehyde

There total 4 articles about 5-(Thiophen-3-yl)nicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 223563-61-9
3-(hydroxymethyl)-5-(3-thiophene)pyridine

: 342601-30-3
3-formyl-5-(3-thiophene)pyridine

Guidance literature:: With sodium acetate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm010246u

Reference yield:

: 113118-81-3
5-bromopyridine-3-carbaldehyde

: 6165-69-1
Thien-3-ylboronic acid

: 342601-30-3
3-formyl-5-(3-thiophene)pyridine

Guidance literature:: 5-bromopyridine-3-carbaldehyde; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dichloro-ethane; at 20 ℃; for 0.0833333h;

Thien-3-ylboronic acid; In 1,2-dichloro-ethane; for 0.166667h;

With sodium carbonate; In water; 1,2-dichloro-ethane; for 12h; Heating / reflux;

Reference yield:

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 342601-30-3
3-formyl-5-(3-thiophene)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 29 percent / BH₃*THF / tetrahydrofuran / 4 h / Heating

2: 61 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol / 20 h / 70 °C

3: 52 percent / PCC; AcONa / CH₂Cl₂ / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium acetate; sodium carbonate; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; toluene; 2: Suzuki coupling reaction;
DOI:10.1021/jm010246u