4-Ethyl-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 4-Ethyl-1,2,3,4-tetrahydroquinoline
• CAS No.: 22494-02-6
• Molecular Formula: C11H15N
• European Community (EC) Number: 894-299-2
• Nikkaji Number: J1.237.455K
• Mol file: 22494-02-6.mol

Synonyms:4-ethyl-1,2,3,4-tetrahydroquinoline;22494-02-6;(r/s)-4-ethyl-1,2,3,4-tetrahydroquinoline;SCHEMBL6648615;VWGKOUAMOLNBMK-UHFFFAOYSA-N;AKOS013181621;CS-0225278;(R/S)-4-ethyl-1,2,3,4,-tetrahydroquinoline;EN300-1232914

Chemical Property of 4-Ethyl-1,2,3,4-tetrahydroquinoline

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 161.120449483
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1CCNC2=CC=CC=C12

Technology Process of 4-Ethyl-1,2,3,4-tetrahydroquinoline

There total 4 articles about 4-Ethyl-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

ethylmagnesium bromide (925-90-6) + (1-(trimethylsilyl)quinolin-1-ium trifluoromethanesulfonate) → 2-ethylquinoline (1613-34-9) + 4-ethylquinoline (19020-26-9) + 2-ethyl-1,2,3,4-tetrahydroquinoline (42835-88-1) + (R/S)-4-ethyl-1,2,3,4-tetrahydroquinoline (22494-02-6)

Guidance literature:

In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jo990586b

Reference yield: 42.0%

ethylmagnesium bromide (925-90-6) + 1-triphenylsilanyl-quinolinium; trifluoro-methanesulfonate → 2-ethylquinoline (1613-34-9) + 4-ethylquinoline (19020-26-9) + (R/S)-4-ethyl-1,2,3,4-tetrahydroquinoline (22494-02-6)

Guidance literature:

In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jo990586b

Reference yield: 37.0%

ethylmagnesium bromide (925-90-6) + 1-triethylsilanyl-quinolinium; trifluoro-methanesulfonate → 2-ethylquinoline (1613-34-9) + 4-ethylquinoline (19020-26-9) + (R/S)-4-ethyl-1,2,3,4-tetrahydroquinoline (22494-02-6)

Guidance literature:

In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jo990586b

upstream raw materials:

ethylmagnesium bromide

Downstream raw materials:

LG121071