Cyclohexanone, 2-methyl-, (2R)-

Base Information

• Chemical Name: Cyclohexanone, 2-methyl-, (2R)-
• CAS No.: 22554-29-6
• Molecular Formula: C7H12O
• Molecular Weight: 112.172
• Mol file: 22554-29-6.mol

Synonyms:

Chemical Property of Cyclohexanone, 2-methyl-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanone, 2-methyl-, (2R)-

There total 52 articles about Cyclohexanone, 2-methyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1R,2R)-1-((R)-2-methylcyclohexylideneamino)-6-nitroindan-2-ol → (S)-2-methylcyclohexanone (22554-27-4) + (R)-2-methylcyclohexanone (22554-29-6)

Guidance literature:

With acetic acid buffer; sodium acetate; In hexane; at 0 ℃; pH=4.1; Title compound not separated from byproducts;

DOI:10.1021/ja029715n

Reference yield: 93.0%

2-methyl-2-cyclohexen-1-one (1121-18-2) → (R)-2-methylcyclohexanone (22554-29-6)

Guidance literature:

With glucose-6-phosphate; pentaerythritol tetranitrate reductase; nicotinamide adenine dinucleotide phosphate; glucose 6-phosphate dehydrogenase; at 30 ℃; for 24h; pH=7; optical yield given as %ee; stereoselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1002/adsc.200900574

Reference yield: 79.0%

(2R,5R)-5-isopropenyl-2-methylcyclohexanone (5524-05-0) → (R)-2-methylcyclohexanone (22554-29-6)

Guidance literature:

(2R,5R)-5-isopropenyl-2-methylcyclohexanone; With methanol; ozone;

With ferrous(II) sulfate heptahydrate; thiophenol; at -78 - 20 ℃; for 0.5h;

DOI:10.1126/science.aaw4212

upstream raw materials:

1-methylcyclohex-1-ene

2-methyl-2-cyclohexen-1-one

2-methylenecyclohexanone

1-trimethylsilyloxy-2-methyl-1-cyclohexene

Downstream raw materials:

(+/-)-trans-2-methylcyclohexanol

cis-2-methylcyclohexanol

(+)-(R)-6-methylcyclohex-2-en-1-one

cis-2-methylcyclohexan-1-ol

Refernces

• 1、 Luan, Pengqian,Liu, Yunting,Li, Yongxing,Chen, Ran,Huang, Chen,Gao, Jing,Hollmann, Frank,Jiang, Yanjun. "Aqueous chemoenzymatic one-pot enantioselective synthesis of tertiary α-aryl cycloketonesviaPd-catalyzed C-C formation and enzymatic C=C asymmetric hydrogenation". supporting information. p. 1960 - 1964. Retrieved 2021/03/26.
• 2、 Rauch, Marine C. R.,Gallou, Yann,Delorme, Léna,Paul, Caroline E.,Arends, Isabel W. C. E.,Hollmann, Frank. "Metals in Biotechnology: Cr-Driven Stereoselective Reduction of Conjugated C=C Double Bonds". . p. 1112 - 1115. Retrieved 2019/12/27.