(2E)-N-(2-chlorophenyl)-2-(hydroxyimino)acetamide

Base Information

• Chemical Name: (2E)-N-(2-chlorophenyl)-2-(hydroxyimino)acetamide
• CAS No.: 14722-82-8
• Molecular Formula: C8H7 Cl N2 O2
• Molecular Weight: 198.609
• Mol file: 14722-82-8.mol

Synonyms:14722-82-8;(2E)-N-(2-chlorophenyl)-2-(hydroxyimino)acetamide;2-Chloroisonitrosoacetanilide;(2E)-N-(2-chlorophenyl)-2-hydroxyiminoacetamide;N-(2-chlorophenyl)-2-(hydroxyimino)acetamide;N-(2-chlorophenyl)-2-(N-hydroxyimino)acetamide;53629-64-4;N-(2-Chlorophenyl)-2-hydroxyimino-acetamide;(E)-N-(2-Chlorophenyl)-2-(hydroxyimino)acetamide;(2E)-N-(2-chlorophenyl)-2-(N-hydroxyimino)acetamide;N-(2-chlorophenyl)-2-(hydroxyimino)ethanamide;starbld0037013;Acetamide, N-(2-chlorophenyl)-2-(hydroxyimino)-;HMS553H10;VFTUFVGOXLZZPW-BJMVGYQFSA-N;MFCD00136207;STK402268;AKOS001286716;Glyoxylanilide, 2'-chloro-, 2-oxime;LS-04558;CS-0242672;EN300-25370;A919563;(2E)-N-(2-Chlorophenyl)-2-(hydroxyimino)ethanamide;(2E)-N-(2-Chlorophenyl)-2-(hydroxyimino)ethanamide #;Z203881852

Chemical Property of (2E)-N-(2-chlorophenyl)-2-(hydroxyimino)acetamide

Chemical Property:

• PSA: 61.69000
• Density: 1.359g/cm³
• LogP: 1.81150
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 198.0196052
• Heavy Atom Count: 13
• Complexity: 208

Purity/Quality:

98% ^*data from raw suppliers

N-(2-Chlorophenyl)-2-(hydroxyimino)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NC(=O)C=NO)Cl
• Isomeric SMILES: C1=CC=C(C(=C1)NC(=O)/C=N/O)Cl

Technology Process of (2E)-N-(2-chlorophenyl)-2-(hydroxyimino)acetamide

There total 5 articles about (2E)-N-(2-chlorophenyl)-2-(hydroxyimino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

chloral (75-87-6) + o-chloroaniline (95-51-2) → N-(2-chlorophenyl)-2-isonitrosoacetanilide (14722-82-8)

Guidance literature:

With hydroxyammonium sulfate; sodium sulfate; In ethanol; at 60 - 80 ℃; for 6h;

DOI:10.1016/S0040-4039(97)00140-8

Reference yield: 70.0%

chloral hydrate (302-17-0) + 2-chloroaniline hydrochloride (137-04-2) → N-(2-chlorophenyl)-2-isonitrosoacetanilide (14722-82-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium sulfate; In water; at 35 ℃; for 4h; Reflux;

Reference yield:

chloral hydrate (302-17-0) + o-chloroaniline (95-51-2) → N-(2-chlorophenyl)-2-isonitrosoacetanilide (14722-82-8)

Guidance literature:

With sulfuric acid; hydroxylamine sulfate;

upstream raw materials:

chloral hydrate

o-chloroaniline

chloral

(2-chlorophenylcarbamoyl)methyl diacetate

Downstream raw materials:

7-Chloroindole-2,3-dione 3-Oxime

7-chloro-1H-indole

7-chloro-1-methylindoline-2,3-dione

2-(7-chloro-2,3-dioxoindolin-1-yl)-N-phenylacetamide

Refernces

• 1、 Reddy Panyam, Pradeep Kumar,Ugale, Bharat,Gandhi, Thirumanavelan. "Palladium(II)/N-Heterocyclic Carbene Catalyzed One-Pot Sequential α-Arylation/Alkylation: Access to 3,3-Disubstituted Oxindoles". supporting information. p. 7622 - 7632. Retrieved 2018/06/22.
• 2、 Wang, Zheng,Wang, Cuiling,Sun, Yanni,Zhang, Ning,Liu, Zhulan,Liu, Jianli. "A novel strategy to the synthesis of 4-anilinoquinazoline derivatives". . p. 906 - 913. Retrieved 2014/01/23.