4,4'-Dihydroxybenzanilide

Base Information

• Chemical Name: 4,4'-Dihydroxybenzanilide
• CAS No.: 22744-42-9
• Molecular Formula: C13H11NO3
• Molecular Weight: 229.235
• DSSTox Substance ID: DTXSID20359188
• Nikkaji Number: J1.745.796I
• Wikidata: Q82140264
• ChEMBL ID: CHEMBL333685
• Mol file: 22744-42-9.mol

Synonyms:4,4'-dihydroxybenzanilide;22744-42-9;4-hydroxy-N-(4-hydroxyphenyl)benzamide;Benzamide, 4-hydroxy-N-(4-hydroxyphenyl)-;Oprea1_053575;SCHEMBL899585;CHEMBL333685;DTXSID20359188;WCTPJCYSFNTVKJ-UHFFFAOYSA-N;STK371407;AKOS003627434;4-hydroxy-N-(4-hydroxyphenyl)-benzamide

Chemical Property of 4,4'-Dihydroxybenzanilide

Chemical Property:

• PSA: 73.05000
• LogP: 2.73410
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 229.07389321
• Heavy Atom Count: 17
• Complexity: 253

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)O)O

Technology Process of 4,4'-Dihydroxybenzanilide

There total 12 articles about 4,4'-Dihydroxybenzanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-amino-phenol (123-30-8) + 4-hydroxy-benzoic acid (99-96-7) → 4-hydroxy-N-(4-hydroxyphenyl)benzamide (22744-42-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetone; for 12h; Inert atmosphere; Reflux;

Reference yield: 63.0%

4-Trimethylsilanyloxy-N-(4-trimethylsilanyloxy-phenyl)-benzamide (345317-68-2) → 4-hydroxy-N-(4-hydroxyphenyl)benzamide (22744-42-9)

Guidance literature:

In chloroform; for 2h; Ambient temperature;

Reference yield: 34.0%

pyridine (110-86-1) + 4-hydroxy-benzoic acid (99-96-7) → 4-hydroxy-N-(4-hydroxyphenyl)benzamide (22744-42-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

4-Trimethylsilanyloxy-N-(4-trimethylsilanyloxy-phenyl)-benzamide

4-[(trimethylsilyl)oxy]benzoic acid trimethylsilyl ester

4-(trimethylsilyloxy)benzoyl chloride

4-hydroxy-benzoic acid

Refernces

• 1、 -. "ORGANIC COLORANT, COLORING COMPOSITION, AND INKJET INK". Paragraph 0098; 0099; 0100; 0101; 0102. . Retrieved 2019/01/25.
• 2、 Caldarelli, Antonio,Minazzi, Paolo,Canonico, Pier Luigi,Genazzani, Armando A.,Giovenzana, Giovanni B.. "N-Arylbenzamides: Extremely simple scaffolds for the development of novel estrogen receptor agonists". . p. 148 - 152. Retrieved 2013/04/23.